1.A.7.1.9
Purinorepector, P2X7 (P2RX7) of 595 aas and 2 TMSs. The crystal structure in complex with a series of allosteric antagonists were published,
giving insight into the mechanism of channel antagonism (Pasqualetto et al. 2018). A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function (Skarratt et al. 2020).
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| Accession Number: | G1M6C4 |
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| Protein Name: | p2X purinoceptor |
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| Length: | 595 |
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| Molecular Weight: | 68341.00 |
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| Species: | Ailuropoda melanoleuca (Giant panda) [9646] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
ion |
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1: TMPACCSWKD VFQYETNKVL RIQSTNYGTI KWIFHVLVFS YISFALISDK RYQKKEPLIS
61: SVHTKVKGIA EVKAEILENG MKKMVSGVFD TADYTFPLQG NSFFVMTNFI KTEGQQQGLC
121: PDFPTRRTIC SSDRGCKKGR MDPQSKGIQT GRCVVYKERL KTCEVSAWCP IEEVEDAPRP
181: ALLNSAENFT VLIKNNIDFP GHNYTTRNIL PGVNITCTFH KTQNPQCPIF RLGDIFQETG
241: DNFSDVAIQG GIMGIEIYWD CNLDGWFHHC RPKYSFRRLD DKTTNESLYP GYNFRYAKYY
301: KENNVEKRTL IKVFGIRFDI LVFGTGGKFN VIQLAVYIGS VISYFGLATV FIDILINTYS
361: SKCCRSRIYP CFKCCEYCAV NEYYYRKQSE PIAEPKPTLK YVSFVDETHI RMVDQQLLGK
421: SLQNVKGEKV QRPSVDFTDL SRLSLSLCDP TPIPGQPEEM QLFSEEVTPR SSNSPDWCQC
481: GHCLPSQLPE SHRCLEELCC RKKAGACITT SEPFRKLVLS RQVLQFLLLY QEPLLVLDGN
541: SSSRLRHCAY RCYTTWRFGS PDLADFAILP SCCRWRIRRE FPKSEGQYTG FQSPY