1.A.77.1.12
The mitochondrial calcium uniporter regulatory subunit MCUb of 336 aas; part of the MCU complex (Sancak et al. 2013). MCU regulates procoagulant platelet formation (Kholmukhamedov et al. 2018) and interacts with the c-subunit of the mitochondrial ATPase (Huang and Docampo 2020). It functions in animals (but not in fungi or protozoans) with another protein, EMRE or SMDT1 of 107 aas (TC# 8.A.45.1.1) that interacts with and renders the channel functional (MacEwen et al. 2020). The mitochondrial calcium uniporter of pulmonary type 2 cells determines the severity of acute lung injury (Islam et al. 2022).
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| Accession Number: | Q9NWR8 |
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| Protein Name: | Mitochondrial calcium uniporter regulatory subunit MCUb |
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| Length: | 336 |
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| Molecular Weight: | 39082.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
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1: MLQRGLWPWR TRLLPTPGTW RPARPWPLPP PPQVLRVKLC GNVKYYQSHH YSTVVPPDEI
61: TVIYRHGLPL VTLTLPSRKE RCQFVVKPML STVGSFLQDL QNEDKGIKTA AIFTADGNMI
121: SASTLMDILL MNDFKLVINK IAYDVQCPKR EKPSNEHTAE MEHMKSLVHR LFTILHLEES
181: QKKREHHLLE KIDHLKEQLQ PLEQVKAGIE AHSEAKTSGL LWAGLALLSI QGGALAWLTW
241: WVYSWDIMEP VTYFITFANS MVFFAYFIVT RQDYTYSAVK SRQFLQFFHK KSKQQHFDVQ
301: QYNKLKEDLA KAKESLKQAR HSLCLQMQVE ELNEKN