1.A.77.1.5
Fungal MCU homologue of 493 aas and 2 TMS. The cryo-electron microscopy structure of the full-length MCU to an overall resolution of ~3.7 Å has been determined (Yoo et al. 2018). The structure reveals a tetrameric architecture, with the soluble and transmembrane domains adopting different symmetric arrangements within the channel. The conserved W-D-Phi-Phi-E-P-V-T-Y sequence motif of the MCU pore forms a selectivity filter comprising two acidic rings separated by one helical turn along the central axis of the channel pore (Yoo et al. 2018).
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| Accession Number: | Q7S4I4 |
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| Protein Name: | Predicted protein |
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| Length: | 493 |
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| Molecular Weight: | 56997.00 |
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| Species: | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [367110] |
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| Number of TMSs: | 2 |
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| Substrate |
calcium(2+), magnesium(2+) |
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1: MNCVRMRLQC RLMPSSNTLA RWCLESPQKN LTLHRPRISN VALRQASTSV SPKTRETEAE
61: AKAKKLDQKR LDEHEEEVRA REQQVRRPWH REGADKPPVE GNADPIAKGK LLTTPTRLLK
121: LILPLPLRVE KDQKNNGRNN EYGRSISLNS DIQPLALLIH PQQPLSYVER LIQAELPPVV
181: ENGQEKIPNV YFRAEDSEQG DQKPTSRAEA RSKDDGGEPS EYNTNLSHVA SYSGLGHRGP
241: KRSSQDKRWV RWSSSTEMGD FIRDAARGRE FAIEIEGYNI EMRVSVPSFG DRTYYMRQRL
301: RKMSSEIDGL AKIKHECDLL AHRSAHRLAK GGFGLLAGWW GVVYYVTFHT EFGWDLVEPV
361: TYLAGLTTIM GGYLWFLYIN KDLSYKAAMN VTVSRRQHAL YEMKGFDIER WEQLVQDANA
421: LRREIRVIAV EYDVDWDETR DVGEDVKDVL DEERSRRDDE HRSIEKEKDE KFTEDEKRKR
481: KKDKESKETS GDS