1.A.79.1.2
The human SIDT1 protein (Duxbury et al. 2005; Pratt et al. 2012). This protein as well as SidT2 may be cholesterol transporters (Méndez-Acevedo et al. 2017), although they are annotated as RNA transporters, in accordance with several earlier publications. Morreover, SIDT1 localizes to endolysosomes and mediates double-stranded RNA transport into the cytoplasm (Nguyen et al. 2019).
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| Accession Number: | Q9NXL6 |
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| Protein Name: | SID1 transmembrane family member 1 |
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| Length: | 827 |
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| Molecular Weight: | 93839.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
double-stranded RNA |
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| RefSeq: |
NP_060169.2
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| Entrez Gene ID: |
54847
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| OMIM: |
606816 gene
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| KEGG: |
hsa:54847
hsa:54847
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[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T. et.al. 14702039
[2] “The DNA sequence, annotation and analysis of human chromosome 3.” Muzny D.M. et.al. 16641997
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T. et.al. 14702039
[5] “The DNA sequence, annotation and analysis of human chromosome 3.” Muzny D.M. et.al. 16641997
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
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1: MRGCLRLALL CALPWLLLAA SPGHPAKSPR QPPAPRRDPF DAARGADFDH VYSGVVNLST
61: ENIYSFNYTS QPDQVTAVRV YVNSSSENLN YPVLVVVRQQ KEVLSWQVPL LFQGLYQRSY
121: NYQEVSRTLC PSEATNETGP LQQLIFVDVA SMAPLGAQYK LLVTKLKHFQ LRTNVAFHFT
181: ASPSQPQYFL YKFPKDVDSV IIKVVSEMAY PCSVVSVQNI MCPVYDLDHN VEFNGVYQSM
241: TKKAAITLQK KDFPGEQFFV VFVIKPEDYA CGGSFFIQEK ENQTWNLQRK KNLEVTIVPS
301: IKESVYVKSS LFSVFIFLSF YLGCLLVGFV HYLRFQRKSI DGSFGSNDGS GNMVASHPIA
361: ASTPEGSNYG TIDESSSSPG RQMSSSDGGP PGQSDTDSSV EESDFDTMPD IESDKNIIRT
421: KMFLYLSDLS RKDRRIVSKK YKIYFWNIIT IAVFYALPVI QLVITYQTVV NVTGNQDICY
481: YNFLCAHPLG VLSAFNNILS NLGHVLLGFL FLLIVLRRDI LHRRALEAKD IFAVEYGIPK
541: HFGLFYAMGI ALMMEGVLSA CYHVCPNYSN FQFDTSFMYM IAGLCMLKLY QTRHPDINAS
601: AYSAYASFAV VIMVTVLGVV FGKNDVWFWV IFSAIHVLAS LALSTQIYYM GRFKIDLGIF
661: RRAAMVFYTD CIQQCSRPLY MDRMVLLVVG NLVNWSFALF GLIYRPRDFA SYMLGIFICN
721: LLLYLAFYII MKLRSSEKVL PVPLFCIVAT AVMWAAALYF FFQNLSSWEG TPAESREKNR
781: ECILLDFFDD HDIWHFLSAT ALFFSFLVLL TLDDDLDVVR RDQIPVF