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1.A.8.10.10
Aquaporin TIP2-1 (Delta-tonoplast intrinsic protein) (Delta-TIP) (Tonoplast intrinsic protein 2-1) (AtTIP2;1) (Daniels et al. 1996). Transports water and ammonia, and can be activated by mercury (Kirscht et al. 2016). The 3-d structure is known to 1.2Å resolution (Kirscht et al. 2016). It may participate in vacuolar compartmentation and detoxification of ammonium.

Accession Number:Q41951
Protein Name:Aquaporin TIP2-1
Length:250
Molecular Weight:25027.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate water

Cross database links:

Entrez Gene ID: 820870   
Pfam: PF00230   
KEGG: ath:AT3G16240   

Gene Ontology

GO:0042807 C:central vacuole
GO:0009941 C:chloroplast envelope
GO:0005794 C:Golgi apparatus
GO:0016021 C:integral to membrane
GO:0009505 C:plant-type cell wall
GO:0009705 C:plant-type vacuole membrane
GO:0005886 C:plasma membrane
GO:0009506 C:plasmodesma
GO:0000326 C:protein storage vacuole
GO:0051739 F:ammonia transmembrane transporter activity
GO:0015200 F:methylammonium transmembrane transporter activity
GO:0015250 F:water channel activity

References (10)

[1] “Characterization of a new vacuolar membrane aquaporin sensitive to mercury at a unique site.”  Daniels M.J.et.al.   8624437
[2] “Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10819329
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “An inventory of 1152 expressed sequence tags obtained by partial sequencing of cDNAs from Arabidopsis thaliana.”  Hoefte H.et.al.   8281187
[5] “Further progress towards a catalogue of all Arabidopsis genes: analysis of a set of 5000 non-redundant ESTs.”  Cooke R.et.al.   8580968
[6] “Random GFP::cDNA fusions enable visualization of subcellular structures in cells of Arabidopsis at a high frequency.”  Cutler S.R.et.al.   10737809
[7] “From genome to function: the Arabidopsis aquaporins.”  Quigley F.et.al.   11806824
[8] “Urea transport by nitrogen-regulated tonoplast intrinsic proteins in Arabidopsis.”  Liu L.-H.et.al.   14576283
[9] “Tonoplast intrinsic proteins AtTIP2;1 and AtTIP2;3 facilitate NH3 transport into the vacuole.”  Loque D.et.al.   15665250
[10] “Arabidopsis tonoplast proteins TIP1 and TIP2 interact with the cucumber mosaic virus 1a replication protein.”  Kim M.J.et.al.   17030879
Structure:
5i32     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAGVAFGSFD DSFSLASLRA YLAEFISTLL FVFAGVGSAI AYAKLTSDAA LDTPGLVAIA 
61:	VCHGFALFVA VAIGANISGG HVNPAVTFGL AVGGQITVIT GVFYWIAQLL GSTAACFLLK 
121:	YVTGGLAVPT HSVAAGLGSI EGVVMEIIIT FALVYTVYAT AADPKKGSLG TIAPLAIGLI 
181:	VGANILAAGP FSGGSMNPAR SFGPAVAAGD FSGHWVYWVG PLIGGGLAGL IYGNVFMGSS 
241:	EHVPLASADF