1.A.8.4.2
Aquaporin-12A (AQP-12) of 295 aas and probably 7 TMSs with an extra N-terminal TMS. It bears a C-terminal KKXX-like ER retention sequence and is found intracelllularly (Ishibashi 2006). It is expressed in elevated amounts in exocrine glandular cells of the pancreas (Danielsson et al. 2014) but is also present in the nuclear envelope. A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis (Zhang et al. 2021).
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| Accession Number: | Q8IXF9 |
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| Protein Name: | Aquaporin-12A |
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| Length: | 295 |
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| Molecular Weight: | 31475.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| Entrez Gene ID: |
375318
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| Pfam: |
PF00230
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| KEGG: |
hsa:375318
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[1] “Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.” Itoh T. et.al. 15809071
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1: MAGLNVSLSF FFATFALCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL
61: LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEQSLPGTL LKLAAQGLGM QAACTLMRLC
121: WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV
181: ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG
241: RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS