1.A.8.9.19
AQP2 (AQP9) of 312 aas and 6 TMSs; transports water, glycerol and urea as well as the drugs, melarsoprol and pentamidine (Schmidt et al. 2018). CCCP and gramicidin but not nigericin inhibit Trypanosoma brucei Aquaglyceroporins Aqp2 and Aqp3 at neutral pH (Petersen and Beitz 2020).
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| Accession Number: | Q388I5 |
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| Protein Name: | Aquaporin 9, putative |
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| Length: | 312 |
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| Molecular Weight: | 33594.00 |
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| Species: | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [185431] |
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| Number of TMSs: | 6 |
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| Substrate |
water, urea, glycerol |
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1: MQSQPDNVAY PMELQAVNKD GTVEVRVQGN VDNSSNERWD ADVQKHEVAE AQEKPVGGIN
61: FWAPRELRLN YRDYVAEFLG NFVLIYIAKG AVITSLLVPD FGLLGLTIGI GVAVTMALYV
121: SLGISGGHLN SAVTVGNAVF GDFPWRKVPG YIAAQMLGTF LGAACAYGVF ADLLKAHGGG
181: ELIAFGEKGI AWVFAMYPAE GNGIFYPIFA ELISTAVLLL CVCGIFDPNN SPAKGYETVA
241: IGALVFVMVN NFGLASPLAM NPSLDFGPRV FGAILLGGEV FSHANYYFWV PLVVPFFGAI
301: LGLFLYKYFL PH