1.A.8.9.3
Major aquaglyceroporin, LmAQP1: transports water, glycerol, methylglyoxal, trivalent metalloids such as arsenite and antimonite, dihydroxyacetone and sugar alcohols. Also takes up the activated form or the drug, pentostam.  It localizes to the flagellum of the Leishmania promastigotes and is used to regulate volume in response to hypoosmotic stress; it functions in osmotaxis (Figarella et al., 2005; Gourbal et al, 2004).  The first line treatment for cutaneous leishmaniasis is pentavalent antimony such as sodium stibogluconate (pentostam) and meglumine antimonite (glucantime), and both compounds are transported by LmAQP1 (Eslami et al. 2020). The mutation G133D in the Leishmania guyanensis AQP1 is highly destabilizing (Tunes et al. 2021).