1.A.85.1.4
Polyprotein of 2333 aas (includes the viroporin peptide, NS2B). Viroporin activity for the NS2B protein has been demonstrated (Ao et al. 2015).
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| Accession Number: | P03308 |
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| Protein Name: | Genome polyprotein |
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| Length: | 2333 |
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| Molecular Weight: | 259162.00 |
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| Species: | Foot-and-mouth disease virus (isolate Bovine/United Kingdom/A12Valle119/1932 serotype A) (FMDV) [12114] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Host cytoplasmic vesicle membrane1 / Peripheral membrane protein2 / Cytoplasmic side3 |
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| Substrate |
molecule |
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1: MNTTNCFIAL VHAIREIRAF FLSRATGKME FTLYNGERKT FYSRPNNHDN CWLNTILQLF
61: RYVDEPFFDW VYNSPENLTL AAIKQLEELT GLELHEGGPP ALVIWNIKHL LQTGIGTASR
121: PSEVCMVDGT DMCLADFHAG IFLKGQEHAV FACVTSNGWY AIDDEDFYPW TPDPSDVLVF
181: VPYDQEPLNG GWKANVQRKL KGAGQSSPAT GSQNQSGNTG SIINNYYMQQ YQNSMDTQLG
241: DNAISGGSNE GSTDTTSTHT TNTQNNDWFS KLASSAFTGL FGALLADKKT EETTLLEDRI
301: LTTRNGHTTS TTQSSVGVTY GYSTEEDHVA GPNTSGLETR VVQAERFFKK FLFDWTTDKP
361: FGHLEKLELP TDHHGVFGHL VDSYAYMRNG WDVEVSAVGN QFNGGCLLVA MVPEWKEFDK
421: REKYQLTLFP HQFISPRTNM TAHITVPYLG VNRYDQYKKH KPWTLVIMVV SPLTVSNTAA
481: TQIKVYANIA PTYVHVAGEL PSKEGIFPVA CSDGYGGLVT TDPKTADPVY GKVYNPPRTN
541: YPGRFTNLLD VAEACPTFLC FDDGKPYVVT RTDDTRLLAK FDVSLAAKHM SNTYLSGIAQ
601: YYTQYSGTIN LHFMFTGSTD SKARYMVAYI PPGVETPPET PEGAAHCIHA EWDTGLNSKF
661: TFSIPYVSAA DYAYTASDTA ETTNVQGWVC IYQITHGKAE GDTLVVSASA GKDFELRLPI
721: DPRSQTTATG ESADPVTTTV ENYGGETQVQ RRHHTDVSFI MDRFVKIKSL NPTHVIDLMQ
781: THQHGLVGAL LRAATYYFSD LEIVVRHDGN LTWVPNGAPE AALSNTGNPT AYNKAPFTRL
841: ALPYTAPHRV LATVYNGTNK YSASGSGVRG DSGSLAPRVA RQLPASFNYG AIKAETIHEL
901: LVRMKRAELY CPRPLLAIEV SSQDRHKQKI IAPGKQLLNF DLLKLAGDVE SNPGPFFFAD
961: VRSNFSKLVD TINQMQEDMS TKHGPDFNRL VSAFEELATG VKAIRTGLDE AKPWYKLIKL
1021: LSRLSCMAAV AARSKDPVLV AIMLADTGLE ILDSTFVVKK ISDSLSSLFH VPAPVFSFGA
1081: PVLLAGLVKV ASSFFRSTPE DLERAEKQLK ARDINDIFAI LKNGEWLVKL ILAIRDWIKA
1141: WIASEEKFVT TTDLVPGILE KQRDLNDPSK YKEAKEWLDN ARQACLKSGN VHIANLCKVV
1201: APAPSKSRPE PVVVCLRGKS GQGKSFLANV LAQAISTHFT GRTDSVWYCP PDPDHFDGYN
1261: QQTVVVMDDL GQNPDGKDFK YFAQMVSTTG FIPPMASLED KGKPFNSKVI IATTNLYSGF
1321: TPRTMVCPDA LNRRFHFDID VSAKDGYKIN NKLDIIKALE DTHTNPVAMF QYDCALLNGM
1381: AVEMKRMQQD MFKPQPPLQN VYQLVQEVIE RVELHEKVSS HPIFKQISIP SQKSVLYFLI
1441: EKGQHEAAIE FFEGMVHDSI KEELRPLIQQ TSFVKRAFKR LKENFEIVAL CLTLLANIVI
1501: MIRETRKRQK MVDDAVNEYI EKANITTDDT TLDEAEKNPL ETSGASTVGF RERTLTGQRA
1561: CNDVNSEPAR PAEEQPQAEG PYTGPLERQR PLKVRAKLPQ QEGPYAGPLE RQKPLKVKAK
1621: APVVKEGPYE GPVKKPVALK VKAKNLIVTE SGAPPTDLQK MVMGNTKPVE LILDGKTVAI
1681: CCATGVFGTA YLVPRHLFAE KYDKIMLDGR AMTDSDYRVF EFEIKVKGQD MLSDAALMVL
1741: HRGNRVRDIT KHFRDTARMK KGTPVVGVVN NADVGRLIFS GEALTYKDIV VCMDGDTMPG
1801: LFAYKAATKA GYCGGAVLAK DGADTFIVGT HSAGGNGVGY CSCVSRSMLL RMKAHVDPEP
1861: HHEGLIVDTR DVEERVHVMR KTKLAPTVAH GVFNPEFGPA ALSNKDPRLN EGVVLDEVIF
1921: SKHKGDTKMS AEDKALFRRC AADYASRLHS VLGTANAPLS IYEAIKGVDG LDAMESDTAP
1981: GLPWAFQGKR RGALIDFENG TVGPEVEAAL KLMEKREYKF ACQTFLKDEI RPMEKVRAGK
2041: TRIVDVLPVE HILYTRMMIG RFCAQMHSNN GPQIGSAVGC NPDVDWQRFG THFAQYRNVW
2101: DVDYSAFDAN HCSDAMNIMF EEVFRTDFGF HPNAEWILKT LVNTEHAYEN KRITVEGGMP
2161: SGCSATSIIN TILNNIYVLY ALRRHYEGVE LDTYTMISYG DDIVVASDYD LDFEALKPHF
2221: KSLGQTITPA DKSDKGFVLG HSITDVTFLK RHFHIDYGTG FYKPVMASKT LEAILSFARR
2281: GTIQEKLTSV AGLAVHSGPD EYRRLFEPFQ GLFEIPSYRS LYLRWVNAVC GDA