1.A.92 The Reovirus Viroporin VP10 (RVP10) Family 

Scylla serrata reovirus (SsRV) is a pathogen that can severely damage mud crab (Scylla serrata) aquaculture. Protein p35 with 2 TMSs, also called VP10, is encoded by the S10 gene. SsRV p35 can induce membrane permeability changes when expressed in Escherichia coli. Expressed in bacterial cells, it exists as monomers under reducing conditions but forms homodimers and homotrimers under non-reducing conditions.  p35 therefore has the properties of a viroporin.  It may resemble NS3-like proteins (TC#9.B.66).