1.A.92 The Reovirus Viroporin VP10 (RVP10) Family
Scylla serrata reovirus (SsRV) is a pathogen that can severely
damage mud crab (Scylla serrata) aquaculture. Protein p35 with 2 TMSs, also called VP10, is encoded by the S10 gene. SsRV p35 can induce membrane permeability changes
when expressed in Escherichia coli. Expressed in bacterial
cells, it exists as monomers under reducing conditions but forms
homodimers and homotrimers under non-reducing conditions. p35 therefore has the properties of a viroporin. It may resemble NS3-like proteins (TC#9.B.66).
This family belongs to the: Viroporin-1 Superfamily.
References associated with 1.A.92 family:
Yuan, Y., D. Fan, S. Zhu, J. Yang, and J. Chen. (2017). Identification and characterization of host cell proteins interacting with Scylla serrata reovirus non-structural protein p35. Virus Genes 53: 317-322. 27943061
Zhang, Z., Y. Yuan, D. Fan, J. Yang, Z. Mao, Y. Yan, and J. Chen. (2015). Scylla serrata reovirus p35 protein expressed in Escherichia coli cells alters membrane permeability. Virus Genes 51: 69-76. 26104656