1.A.99 The Infectious Bronchitis Virus Envelope Small Membrane Protein E (IBV-E) Family.
The E protein is a 108 aa, 2 TMS protein belived to be a viroporin. It interacts with the membrane (M) protein (Lim et al. 2001). The E protein is a component of the viral envelope that plays a central role in virus morphogenesis and assembly. It seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. The E protein acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes and mediates ER stress, thereby modulating virion release, apoptosis, viral fitness, and pathogenesis (Li et al. 2019).