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1.B.14.1.1
FhuE ferric-coprogen receptor of 729 aas and 1 N-terminal TMS.  It is required for the uptake of Fe3+ via coprogen, ferrioxamine B, and rhodotorulic acid (Hantke 1983). The crystal structure of FhuE in complex with coprogen was determined, providing a structural basis to explain its selective promiscuity (Grinter and Lithgow 2019). The structural data, in combination with functional analysis, showed that FhuE has evolved to specifically engage with planar siderophores. A potential evolutionary driver, and a critical consequence of this selectivity, is that it allows FhuE to exclude antibiotics that mimic nonplanar hydroxamate siderophores.  These toxic molecules could otherwise cross the outer membrane barrier through a Trojan horse mechanism (Grinter and Lithgow 2019).

Accession Number:P16869
Protein Name:FhuE aka B1102
Length:729
Molecular Weight:81233.00
Species:Escherichia coli [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate Fe3+-coprogen

Cross database links:

RefSeq: AP_001728.1    NP_415620.1   
Entrez Gene ID: 945649   
Pfam: PF07715    PF00593   
BioCyc: EcoCyc:EG10306-MONOMER    ECOL168927:B1102-MONOMER   
KEGG: ecj:JW1088    eco:b1102   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0005506 F:iron ion binding
GO:0004872 F:receptor activity
GO:0015343 F:siderophore-iron transmembrane transporter ...
GO:0006826 P:iron ion transport
GO:0015891 P:siderophore transport

References (5)

[1] “Sequence of the fhuE outer-membrane receptor gene of Escherichia coli K12 and properties of mutants.”  Sauer U.et.al.   2162465
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Ferric-coprogen receptor FhuE of Escherichia coli: processing and sequence common to all TonB-dependent outer membrane receptor proteins.”  Sauer M.et.al.   3032906
Structure:
6E4V     

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLSTQFNRDN QYQAITKPSL LAGCIALALL PSAAFAAPAT EETVIVEGSA TAPDDGENDY 
61:	SVTSTSAGTK MQMTQRDIPQ SVTIVSQQRM EDQQLQTLGE VMENTLGISK SQADSDRALY 
121:	YSRGFQIDNY MVDGIPTYFE SRWNLGDALS DMALFERVEV VRGATGLMTG TGNPSAAINM 
181:	VRKHATSREF KGDVSAEYGS WNKERYVADL QSPLTEDGKI RARIVGGYQN NDSWLDRYNS 
241:	EKTFFSGIVD ADLGDLTTLS AGYEYQRIDV NSPTWGGLPR WNTDGSSNSY DRARSTAPDW 
301:	AYNDKEINKV FMTLKQQFAD TWQATLNATH SEVEFDSKMM YVDAYVNKAD GMLVGPYSNY 
361:	GPGFDYVGGT GWNSGKRKVD ALDLFADGSY ELFGRQHNLM FGGSYSKQNN RYFSSWANIF 
421:	PDEIGSFYNF NGNFPQTDWS PQSLAQDDTT HMKSLYAATR VTLADPLHLI LGARYTNWRV 
481:	DTLTYSMEKN HTTPYAGLVF DINDNWSTYA SYTSIFQPQN DRDSSGKYLA PITGNNYELG 
541:	LKSDWMNSRL TTTLAIFRIE QDNVAQSTGT PIPGSNGETA YKAVDGTVSK GVEFELNGAI 
601:	TDNWQLTFGA TRYIAEDNEG NAVNPNLPRT TVKMFTSYRL PVMPELTVGG GVNWQNRVYT 
661:	DTVTPYGTFR AEQGSYALVD LFTRYQVTKN FSLQGNVNNL FDKTYDTNVE GSIVYGTPRN 
721:	FSITGTYQF