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1.B.14.1.4
CirA Fe3+-catecholate receptor. Serves as the receptor for the TonB- and proton-dependent uptake of the E. coli bacteriocin, Microcin L (MccL) (Morin et al., 2011). CirA is also the translocator for colicin Ia (Jakes and Finkelstein, 2010). Plays roles in cefiderocol and ceftazidime resistance (Ito et al. 2018).  Genotypic evolution of Klebsiella pneumoniae sequence type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol treatment.  This occurred through plasmid loss, outer membrane porin alteration, and a nonsense mutation in the cirA siderophore gene, resulting in high levels of cefiderocol resistance (Arcari et al. 2023).

Accession Number:P17315
Protein Name:CirA aka CIR aka FEUA aka B2155
Length:663
Molecular Weight:73896.00
Species:Escherichia coli [83333]
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate

Cross database links:

DIP: DIP-9282N
RefSeq: AP_002752.1    NP_416660.1   
Entrez Gene ID: 949042   
Pfam: PF07715    PF00593   
BioCyc: EcoCyc:EG10155-MONOMER    ECOL168927:B2155-MONOMER   
KEGG: ecj:JW2142    eco:b2155   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0004872 F:receptor activity
GO:0005215 F:transporter activity
GO:0006826 P:iron ion transport

References (6)

[1] “Evolutionary relationship between the TonB-dependent outer membrane transport proteins: nucleotide and amino acid sequences of the Escherichia coli colicin I receptor gene.”  Nau C.D.et.al.   2644220
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Cloning and promoter identification of the iron-regulated cir gene of Escherichia coli.”  Griggs D.W.et.al.   3316180
[5] “The lysP gene encodes the lysine-specific permease.”  Steffes C.et.al.   1315732
[6] “Activation of expression of the Escherichia coli cir gene by an iron-independent regulatory mechanism involving cyclic AMP-cyclic AMP receptor protein complex.”  Griggs D.W.et.al.   2160948
Structure:
2HDF   2HDI     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MFRLNPFVRV GLCLSAISCA WPVLAVDDDG ETMVVTASSV EQNLKDAPAS ISVITQEDLQ 
61:	RKPVQNLKDV LKEVPGVQLT NEGDNRKGVS IRGLDSSYTL ILVDGKRVNS RNAVFRHNDF 
121:	DLNWIPVDSI ERIEVVRGPM SSLYGSDALG GVVNIITKKI GQKWSGTVTV DTTIQEHRDR 
181:	GDTYNGQFFT SGPLIDGVLG MKAYGSLAKR EKDDPQNSTT TDTGETPRIE GFSSRDGNVE 
241:	FAWTPNQNHD FTAGYGFDRQ DRDSDSLDKN RLERQNYSVS HNGRWDYGTS ELKYYGEKVE 
301:	NKNPGNSSPI TSESNTVDGK YTLPLTAINQ FLTVGGEWRH DKLSDAVNLT GGTSSKTSAS 
361:	QYALFVEDEW RIFEPLALTT GVRMDDHETY GEHWSPRAYL VYNATDTVTV KGGWATAFKA 
421:	PSLLQLSPDW TSNSCRGACK IVGSPDLKPE TSESWELGLY YMGEEGWLEG VESSVTVFRN 
481:	DVKDRISISR TSDVNAAPGY QNFVGFETGA NGRRIPVFSY YNVNKARIQG VETELKIPFN 
541:	DEWKLSINYT YNDGRDVSNG ENKPLSDLPF HTANGTLDWK PLALEDWSFY VSGHYTGQKR 
601:	ADSATAKTPG GYTIWNTGAA WQVTKDVKLR AGVLNLGDKD LSRDDYSYNE DGRRYFMAVD 
661:	YRF