TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.B.165.1.1









AvrE (DspE) of 1838 aas and a beta (β) structure after secretion from the bacteriial cytoplasm via a type III protein secretion system (TC# 3.A.6) into the host cell and insertion into the plasma membrane of the plant cell where it transports metabolites, water and small molecules such as fluorescene dyes (Nomura et al. 2023).  DspE in Xenopus oocytes resulted in inward and outward currents, permeability to water and osmolarity-dependent oocyte swelling and bursting. Liposome reconstitution confirmed that the DspE channel alone is sufficient to allow the passage of small molecules such as fluorescein dye. Targeted screening of chemical blockers based on the predicted pore size (15-20 Å) of the DspE channel identified polyamidoamine dendrimers as inhibitors of the DspE/AvrE channels. Notably, polyamidoamines broadly inhibit AvrE and DspE virulence activities in Xenopus oocytes and during E. amylovora and P. syringae infections.

Bacteria
Pseudomonadota
AvrE of Erwinia amylovora
1.B.165.1.2









AvrE of 1795 aas with a beta (β) structure; it inserts into the plant cell membrane after secretion from the bacterium via the type III secretion system (TC# 3.A.6) to form pores (Nomura et al. 2023).

Bacteria
Pseudomonadota
AvrE of Pseudomonas syringae
1.B.165.1.3









AvrE-family type 3 secretion system effector of 1625 aas.

Bacteria
Pseudomonadota
AvrE homolog of Dickeya chrysanthemi (Pectobacterium chrysanthemi)
1.B.165.1.4









AvrE-family type 3 secretion system effector of 1839 aa

Bacteria
Pseudomonadota
AvrE of Mixta calida
1.B.165.1.5









DspE-family type 3 secretion system effector of 1829 aas.

Bacteria
Pseudomonadota
DspE of Pantoea agglomerans pv. gypsophilae (Erwinia herbicola)
1.B.165.1.6









AvrE-family type 3 secretion system effector of 1829 aa

Bacteria
Pseudomonadota
AvrE homolog of Brenneria goodwinii
1.B.165.1.7









Type III effector protein AvrE1 of 1437 aa

Bacteria
Pseudomonadota
AvrE of Pseudomonas orientalis
1.B.165.1.8









AvrE-family type 3 secretion system effector of 1889 aa

Bacteria
Pseudomonadota
AvrE homolog of Pseudomonas quasicaspiana
1.B.165.1.9









Averulence protein, DspE of 1614 aas.

Bacteria
Pseudomonadota
DspE (DspA) of Pectobacterium atrosepticum (Erwinia carotovora subsp. atroseptica)   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)