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1.B.5.1.2
Pyrophosphate-selective porin OprO (Hancock et al. 1992).  The residue basis for the selectivity of P2 over Pi has been determined and involves two residues (Modi et al. 2015).  The phosphonic-acid antibiotic fosfomycin is highly permeable through the OprO and OprP channels (Citak et al. 2018). Fosfidomycin is also transported (Lapierre and Hub 2023).

Accession Number:P32977
Protein Name:PORO aka OprO aka PA3280
Length:438
Molecular Weight:47788.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate fosfomycin, diphosphate(4-)

Cross database links:

RefSeq: NP_251970.1   
Entrez Gene ID: 882443   
Pfam: PF07396   
BioCyc: PAER208964:PA3280-MONOMER   
KEGG: pae:PA3280   

Gene Ontology

GO:0009279 C:cell outer membrane
GO:0005886 C:plasma membrane
GO:0046930 C:pore complex
GO:0006811 P:ion transport
GO:0006950 P:response to stress

References (2)

[1] “Polyphosphate-selective porin OprO of Pseudomonas aeruginosa: expression, purification and sequence.”  Siehnel R.J.et.al.   1406271
[2] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043
Structure:
4RJW   4RJX     

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MIRKHSLGFV ASALALAVSA QAFAGTVTTD GADIVIKTKG GLEVATTDKE FSFKLGGRLQ 
61:	ADYSRFDGFY TKNGNTADAA YFRRAFIELG GTAYKDWKYQ INFDLSHNTG SSDNGYFDEA 
121:	SVTYTGFNPV NLKFGRFDPD FGLEKATSSK WVTAPERNAA YELADWINTH QDGMGAQVNS 
181:	TLADMAYLSA GVSAKDADDS DGDSVKQFNF RGVFAPMHEA GNVLHVGVNY AYRDLDDTAF 
241:	DSRIRPRLGM RGIATSGGND AGDNGNRATF GGVSNSPAGS YKDDSVWGLE GAWAMGPFSA 
301:	QAEYLARKLK ADDNAYKDIK AKGYYAQLAY TLTGESRQYK LEGAKFDSVK PENKEIGAWE 
361:	VFYRYDNIKV EDDNVVADTA TREVGDTKAK AHNLGVNWYV NDAVKISAAY VKAKTDKITN 
421:	NNGDDDGDGF VTRLQYVF