1.C.11.1.7
Leukotoxin A, LtxA pore-forming toxin of 1055 aas, exhibiting β-hemolytic activity. Plays a role in immune evasion by lysing human lymphocytes and monocytes. It binds to the LFA-1 integrin on
the surface of the host cell and to cholesterol-containing membranes,
resulting in large LtxA-LFA-1 clusters in lipid rafts (Balashova et al. 2006; Brown et al. 2013). Blocking P2X receptors protects monocytes from LtxA (Fagerberg et al. 2016).
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| Accession Number: | P16462 |
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| Protein Name: | Leukotoxin |
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| Length: | 1055 |
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| Molecular Weight: | 113854.00 |
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| Species: | Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) [714] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Cell outer membrane1 / Peripheral membrane protein2 / Extracellular side3 |
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| Substrate |
molecule |
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1: MATTTLPNTK QQAAQFANSV ADRAKENIDA AKEQLQKALD KLGKTGKKLT LYIPKNYKKG
61: NGLTALIKAA QKLGIEVYHE GKDGPALTNG ILNTGKKLLG LTERGLTLFA PELDKWIQGN
121: KHLSNSVGST GNLTKAIDKV QSVLGTLQAF LNTAFSGMDL DALIKARQNG KNVTDVQLAK
181: ASLNLINELI GTISSITNNV DTFSKQLNKL GEALGQVKHF GSFGDKLKNL PKLGNLGKGL
241: GALSGVLSAI SAALLLANKD ADTATKAAAA AELTNKVLGN IGKAITQYLI AQRAAAGLST
301: TGPVAGLIAS VVSLAISPLS FLGIAKQFDR ARMLEEYSKR FKKFGYNGDS LLGQFYKNTG
361: IADAAITTIN TVLSAIAAGV GAASAGSLVG APIGLLVSAI TSLISGILDA SKQAVFEHIA
421: NQLADKIKAW ENKYGKNYFE NGYDARHSAF LEDSLKLFNE LREKYKTENI LSITQQGWDQ
481: RIGELAGITR NGDRIQSGKA YVDYLKKGEE LAKHSDKFTK QILDPIKGNI DLSGIKGSTT
541: LTFLNPLLTA GKEERKTRQS GKYEFITELK VKGRTDWKVK GVPNSNGVYD FSNLIQHAVT
601: RDNKVLEARL IANLGAKDDY VFVGSGSTIV NAGDGYDVVD YSKGRTGALT IDGRNATKAG
661: QYKVERDLSG TQVLQETVSK QETKRGKVTD LLEYRNYKLD YYYTNKGFKA HDELNSVEEI
721: IGSTLRDKFY GSKFNDVFHG HDGDDLIYGY DGDDRLYGDN GNDEIHGGQG NDKLYGGAGN
781: DRLFGEYGNN YLDGGEGDDH LEGGNGSDIL RGGSGNDKLF GNQGDDLLDG GEGDDQLAGG
841: EGNDIYVYRK EYGHHTITEH SGDKDKLSLA NINLKDVSFE RNGNDLLLKT NNRTAVTFKG
901: WFSKPNSSAG LDEYQRKLLE YAPEKDRARL KRQFELQRGK VDKSLNNKVE EIIGKDGERI
961: TSQDIDNLFD KSGNKKTISP QELAGLIKNK GKSSSLMSSS RSSSMLTQKS GLSNDISRII
1021: SATSGFGSSG KALSASPLQT NNNFNSYANS LATTA