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1.C.110.1.1
The PNC-37 (32 aas) pore-forming peptide derived from the Mdm-2 binding domain of the p53 tumor-supressor protein which is selectively cytotoxic to cancer cells.  The 3-d structure is known from NMR anayses (Sookraj et al. 2010). PNC-27 binds to HDM-2 in a 1:1 stoichiometry to induce pore-formation, and the pores are lined by PNC-27 bound to HDM-2 at the membrane surface with the PNC-27 leader sequence lining the pores (Sarafraz-Yazdi et al. 2022).

Accession Number:P04637
Protein Name:Cellular tumor antigen p53
Length:393
Molecular Weight:43653.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate molecule

Cross database links:

Structure:
1A1U   1AIE   1C26   1DT7   1GZH   1H26   1HS5   1JSP   1KZY   1MA3   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP 
61:	DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK 
121:	SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE 
181:	RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS 
241:	SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP 
301:	PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG 
361:	GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD