1.C.111.1.13
NKG2-D type II protein of 216 aas and 1 central TMS. Functions as an activating and costimulatory
receptor involved in immunosurveillance upon binding to various
cellular stress-inducible ligands displayed at the surface of autologous
tumor cells and virus-infected cells. Provides both stimulatory and
costimulatory innate immune responses on activated killer (NK) cells,
leading to cytotoxic activity (Zafirova et al. 2011). It stimulates perforin-mediated elimination of
ligand-expressing tumor cells; signaling involves calcium influx,
culminating in the expression of TNF-alpha (Zuo et al. 2017).
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| Accession Number: | P26718 |
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| Protein Name: | NKG2-D type II integral membrane protein |
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| Length: | 216 |
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| Molecular Weight: | 25274.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type II membrane protein2 |
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| Substrate |
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1: MGWIRGRRSR HSWEMSEFHN YNLDLKKSDF STRWQKQRCP VVKSKCRENA SPFFFCCFIA
61: VAMGIRFIIM VAIWSAVFLN SLFNQEVQIP LTESYCGPCP KNWICYKNNC YQFFDESKNW
121: YESQASCMSQ NASLLKVYSK EDQDLLKLVK SYHWMGLVHI PTNGSWQWED GSILSPNLLT
181: IIEMQKGDCA LYASSFKGYI ENCSTPNTYI CMQRTV