1.C.111.1.15
C-type lectin domain family 4 member M, CLEC4M or CD209L, of 399 aas and 1 N-terminal TMS. It is a probable pathogen-recognition receptor involved in
peripheral immune surveillance in the liver, and may mediate the endocytosis of
pathogens which are subsequently degraded in lysosomal compartments. It is
a receptor for ICAM3, probably by binding to mannose-like
carbohydrates (Bashirova et al. 2001).
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| Accession Number: | Q9H2X3 |
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| Protein Name: | C-type lectin domain family 4 member M |
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| Length: | 399 |
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| Molecular Weight: | 45350.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MSDSKEPRVQ QLGLLEEDPT TSGIRLFPRD FQFQQIHGHK SSTGCLGHGA LVLQLLSFML
61: LAGVLVAILV QVSKVPSSLS QEQSEQDAIY QNLTQLKAAV GELSEKSKLQ EIYQELTQLK
121: AAVGELPEKS KLQEIYQELT RLKAAVGELP EKSKLQEIYQ ELTRLKAAVG ELPEKSKLQE
181: IYQELTRLKA AVGELPEKSK LQEIYQELTE LKAAVGELPE KSKLQEIYQE LTQLKAAVGE
241: LPDQSKQQQI YQELTDLKTA FERLCRHCPK DWTFFQGNCY FMSNSQRNWH DSVTACQEVR
301: AQLVVIKTAE EQNFLQLQTS RSNRFSWMGL SDLNQEGTWQ WVDGSPLSPS FQRYWNSGEP
361: NNSGNEDCAE FSGSGWNDNR CDVDNYWICK KPAACFRDE