1.C.113.1.12
Progestin (P4) receptor beta of 354 aas and 8 TMSs. It couples to G proteins (Petersen et al. 2013). It seems to act through a Gi mediated pathway and may be involved in oocyte maturation (Petersen et al. 2013). Also binds
dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and
allopregnanolone (Pang et al. 2013).
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| Accession Number: | Q8TEZ7 |
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| Protein Name: | Membrane progestin receptor beta |
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| Length: | 354 |
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| Molecular Weight: | 40464.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MTTAILERLS TLSVSGQQLR RLPKILEDGL PKMPCTVPET DVPQLFREPY IRTGYRPTGH
61: EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFAEAE ALPWASTHSL PLLLFILSSI
121: TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYDRFWLFFL
181: PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FILDISPVAH RVALCHLAGC
241: QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI
301: LLDYQGRQEI FLQRHGPLSV HMACLSFFFL AACSAATAAL LRHKVKARLT KKDS