1.C.113.1.9 The adiponectin receptor 1 or ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003.
Required for normal glucose and fat homeostasis and for maintaining a
normal body weight. ADIPOQ-binding activates a signaling cascade that
leads to increased AMPK activity, and ultimately to increased fatty acid
oxidation, increased glucose uptake and decreased gluconeogenesis. Has
high affinity for globular adiponectin and low affinity for full-length
adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017). It may function with adiponectin to stimulate cholesterol efflux via ABCA1 (Hafiane et al. 2019). The Tyr-Pro dipeptide may function as an AdipoR1 agonist (Lee et al. 2021).
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Accession Number: | Q96A54 |
Protein Name: | Adiponectin receptor protein 1 |
Length: | 375 |
Molecular Weight: | 42616.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
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1: MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE EQTCPVPQEE
61: EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL PDWLKDNDYL LHGHRPPMPS
121: FRACFKSIFR IHTETGNIWT HLLGFVLFLF LGILTMLRPN MYFMAPLQEK VVFGMFFLGA
181: VLCLSFSWLF HTVYCHSEKV SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS
241: IVCVLGISAI IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM
301: GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV HFYGVSNLQE
361: FRYGLEGGCT DDTLL