TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.113.1.1









The Hly III protein
Bacteria
Firmicutes
Hly III of Bacillus cereus
1.C.113.1.2









Hemolysin III-like protein of 229 aas

Bacteria
Spirochaetes
Hemolysin III-like protein of Borrelia miyamotoi
1.C.113.1.3









Hemolysin D channel protein of the hemolysin III family

Bacteria
Proteobacteria
Hemolysin D of Pseudomonas stutzeri
1.C.113.1.4









Hemolysin III of 205 aas

Bacteria
Deinococcus-Thermus
Hemolysin of Thermus thermophilus
1.C.113.1.5









Hemolysin III-like protein of 407 aas

Eukaryota
Bangiophyceae
Hemolysin of Galdieria sulphuraria (Red alga)
1.C.113.1.6









Putative hemolysin III of 262 aas

Bacteria
Actinobacteria
Hemolysin of Corynebacterium diphtheriae
1.C.113.1.7









Hemolysin of 282 aas

Eukaryota
Apicomplexa
Hemolysin of Plasmodium falciparum
1.C.113.1.8









Adiponectin receptor  protein of 340 aas

Eukaryota
Kinetoplastida
Adiponectin receptor of Trypanosoma cruzi
1.C.113.1.9









The adiponectin receptor 1 for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (Tanabe et al. 2015; Yamauchi et al. 2003. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. The 3-d structure revealed ceramidase activity for both ADIPOR1 and ADIPOR2; however, the two structures are substantially different (Vasiliauskaité-Brooks et al. 2017).  It may function with adiponectin to stimulate cholesterol efflux via ABCA1 (Hafiane et al. 2019).

Eukaryota
Metazoa
ADIPOR1 of Homo sapiens
1.C.113.1.10









YqfA protein of unknown function.  It may play a role in furfural resistance (Miller et al. 2009).

Bacteria
Proteobacteria
YqfA of E. coli
1.C.113.1.11









ADIPOR2 of 387 aas and 7 TMSs.  It may funtion in promoting cholesterol efflux together with ADIPOR1 and adiponectin (Hafiane et al. 2019).

Eukaryota
Metazoa
Adiponectin receptor 2, ADIPOR2, of Homo sapiens
1.C.113.1.12









Progestin (P4) receptor beta of 354 aas and 8 TMSs.  It couples to G proteins (Petersen et al. 2013). It seems to act through a Gi mediated pathway and may be involved in oocyte maturation (Petersen et al. 2013). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (Pang et al. 2013).

Eukaryota
Metazoa
Progesterone receptor of Homo sapiens
1.C.113.2.1









The monocyte to macrophage differentiation protein (MMDP)
Eukaryota
Metazoa
MMDP of Homo sapiens
1.C.113.2.2









Monocyte to macrophage differentiation factor 2 of 363 aas and 7 TMSs
Eukaryota
Metazoa
Hemolysin homologue of Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
1.C.113.2.3









Progestin and adipoQ receptor family member 10, PAQR10, of 270 aas and 7 TMSs.  Also called Monocyte to macrophage differentiation factor 2, MMD2. PAQR10 is structurally related to some bacterial hemolysins, pore-forming virulence factors that target mitochondria and regulate apoptosis (Góñez et al. 2008).

Eukaryota
Metazoa
PAQR10 of Homo sapiens