TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.118.1.1









Polybia-Mastoparan-1 peptide, Polybia-MP1 of 14 aas.  Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer properties. Its activity is dependent on phosphatidylserine (PS) and phosphatidyl ethanolamine (PE) in the outer leaflet of cancer cell membranes (Leite et al. 2015). zit is a hemotactic peptide for polymorphonucleated leukocytes (PMNL), but causing no hemolysis to rat erythrocytes and no mast cell degranulation activity at physiological concentrations. It is also a potent antimicrobial peptide against Gram-positive bacteria B. subtilis CCT 2576 (MIC=4 µg/ml), and S. aureus ATCC 6538 (MIC=15 µg/ml) as well as Gram-negative bacteria E. coli ATCC 25922 (MIC=8 µg/ml) and P. aeruginosa ATCC 15422 (MIC=8 µg/ml) (Souza et al. 2005).

Eukaryota
Metazoa, Arthropoda
Polybia-MP1 of Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)
1.C.118.1.2









Mastoparan (MP) of 14 aas.  Potent antimicrobial peptide against both Gram-positive and Gram-negative bacteria. This hemolytic peptide shows potent histamine releasing activities on rat peritoneal mast cells.

Eukaryota
Metazoa, Arthropoda
MP of Protonectarina sylveirae (Brazilian wasp)