1.C.12.1.14
Thiol-activated cytolysin of 500 aas and 1 N-terminal TMS. It is a sulfhydryl-activated toxin that causes cytolysis
by forming pores in cholesterol containing host membranes. After binding
to target membranes, the protein undergoes a major conformation change,
leading to its insertion in the host membrane and formation of an
oligomeric pore complex. Biomimetic nanosponges neutralize this cytolysin, protect the retina, preserve
vision, and may provide an adjunct detoxification therapy for bacterial
infections (LaGrow et al. 2017).
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| Accession Number: | U6S4M9 |
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| Protein Name: | Thiol-activated cytolysin |
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| Length: | 500 |
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| Molecular Weight: | 55582.00 |
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| Species: | Enterococcus faecalis VC1B-1 [1244143] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MNKKFSTCLL IGVIFLIFFS VKSIKAFGSN IENSAINDFI YSLSYDPLKI LRFQGDSISN
61: LPSTESDWRN GVFYVVEKKK KSLSNGSSDI SYLSAGEGNL YPGAIYLANR GLTEGRPTPI
121: SAEKKGLTLT IDLPGLTGTD NQRFVEHPDG GNIKSAINDM IDIWIKKYPQ YEQVPAKVEC
181: EQAQTYSMSQ LETQLGLGIE TVAQKLNVDF SSINKGEKQC IFLKFKQIYY TVSTEAKAKP
241: SEYFSEKVTP YELQRQGVNN DAPPVFVSSV SYGRTVYAAI ETSNTSNKFK LAVDAAINGK
301: DVSSDAELSS LIQESTFNAI VYGGGSKSGV KVINGTLSSI HELIDEGKNF DRNSPAVPIS
361: FNTMFIKDNE QALISKATDY VETIVHEYHS GEINLNHSGA YIARYYIDWD EISYDDKGNE
421: IKKNVSWPEN DMNKTAGFSS QIFIPANARN INVKIIEATG LAWDSWHTIC DKKNLPNVNC
481: REFSIWGTTL APYYVNKIIP