TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.124.1.1









Pandinin2 of 24 aas and 1 TMS.  Forms pores and disrupts membranes of bacteria and fungi (Rodríguez et al. 2014).

Eukaryota
Metazoa
Pandinin-2 of Pandinus imperator
1.C.124.1.2









Heterin-1 of 43 aas and 1 TMS.  Heterin-1 possesses potent activities against both Gram-positive and Gram-negative bacteria. Among the tested bacterial species, Heterin-1 is the most active against Bacillus megaterium and Micrococcus luteus with MICs of 4.0 μM for both (Wu et al. 2014).

Eukaryota
Metazoa
Heterin-1 of Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black scorpion)
1.C.124.1.3









Venom toxin of 73 aas and 1 TMS.

Eukaryota
Metazoa
Venom toxin of Hemiscorpius lepturus (scorpion)
1.C.124.1.4









Scorpion toxin, OcyC3, of 75 aas and 1 TMS. Also called antimicrobial peptide NDBP 4.1.

Eukaryota
Metazoa
OcyC3 of Opisthacanthus cayaporum (South American scorpion)
1.C.124.1.5









Ponericin-W5 of 24 aas and 1 TMS. Has a broad spectrum of activities against both Gram-positive and Gram-negative bacteria as well as Saccharomyces cerevisiae. It also has insecticidal and hemolytic activities (Orivel et al. 2001).

Eukaryota
Metazoa
Ponericin-W5 of Pachycondyla goeldii (Ponerine ant)
1.C.124.2.1









Pandinin 1, Pin1, of 44 aas and 0 TMS.  Pin1 is located at the membrane-water interface, approximately parallel to the bilayer surface. Solid-state NMR results correlated well with the observed biological activity of pin1 in red blood cells and bacteria (Nomura et al. 2005). Pin-1 and Pin-2 are not demonstrably homologous.

Eukaryota
Metazoa
Pin-1 of Pandinus imperator