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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
1.C.137.1.1	Gasdermin bGSDM of 259 aas and 1 possible TMS at residue 85. It is the precursor of a pore-forming protein involved in defense against bacteriophages. Expression of gasdermin bGSDM and the neighboring protease gene (Ga0098714_109514) is toxic in E.coli on solid medium (Johnson et al. 2022). Cleavage of this precursor by its dedicated protease releases the active moiety (gasdermin bGSDM, N-terminus), which inserts into membranes, forming pores and triggering cell death.	Bacteria	Pseudomonadota	Gasdermin bGSDM of Bradyrhizobium tropiciagri
1.C.137.1.2	Uncharacterized protein of 267 aas and 1 possible TMS near the C-terminus of the protein.	Bacteria	Pseudomonadota	UP of Ruegeria atlantica
1.C.137.1.3	Uncharacterized protein of 272 aas and 1 or 2 moderately hydrophobic TMSs near the C-terminus of the protein.	Bacteria	Pseudomonadota	UP of Thiococcus pfennigii
1.C.137.1.4	Uncharacterized protein of 271 aas and possible 3 TMSs, one at about residue 90, and two between residues 190 and 225.	Bacteria	Pseudomonadota	UP of Lysobacter enzymogenes
1.C.137.1.5	Uncharacterized protein of 267 aas and at least 1 possible TMS between residues 80 and 100, and possibly several less hydrophobic peaks towards the C-terminus of the protein.	Bacteria	Bacteroidota	UP of Spirosoma sp. KCTC 72228
1.C.137.1.6	Uncharacterized protein of 272 aas with no strongly hydrophobic peaks that could be TMSs.	Bacteria	Pseudomonadota	UP of Azospirillum picis
1.C.137.1.7	Uncharacterized protein of 267 aas with possibly two TMSs between residues 80 and 120.	Bacteria	Thermodesulfobacteriota	UP of Geobacter sp.
1.C.137.1.8	Gasdermin of 268 aas and possibly one TMS at residue 225. The 3-D structure has been determined (PDB# 7N52_A; Johnson et al. 2022).	Bacteria	Bacteroidota	Gasdermin of Runella zeae
1.C.137.1.9	Uncharacterized protein of 266 aas and possibly 1 or 2 TMSs.	Bacteria	Bacteroidota	UP of Cytophagia bacterium (microbial mat metagenome)
1.C.137.1.10	Uncharacterized protein of 350 aas and 1 putative TMS.	Bacteria	Actinomycetota	UP of Streptomyces sp. DSM 40750
1.C.137.1.11	Uncharacterized protein of 233 aas and one possible TMS at about residue 80.	Bacteria	Bacteroidota	UP of Mangrovivirga sp. M17
1.C.137.1.12	Uncharacterized protein of 286 aas and possibly 1 or 2 TMSs.	Bacteria	Pseudomonadota	UP of Methylobacteriaceae
1.C.137.1.13	Uncharacterized protein of 233 aas and possibly 3 TMSs, 2 between residues 80 and 130, and one C-terminal.	Archaea	Euryarchaeota	UP of Methanomicrobiales archaeon
1.C.137.1.14	Uncharacterized protein of 249 aas and possibly as many as 3 mderately hydrophobic TMSs, two between residues 150 and 190, and one more at the C-terminus.	Bacteria	Candidatus Coatesbacteria	UP of Candidatus Coatesbacteria bacterium
1.C.137.1.15	Uncharacterized protein of 258 aas and possibly 3 TMSs, two near the N-terminus (residues 10 - 50). This protein shows sequence similarity with members of TC subclasses 1, 2, 4, and 5 in family 1.C.137.	Bacteria	Bacteroidota	UP of Pinibacter aurantiacus
1.C.137.1.16	Uncharacterized protein of 288 aas and possibly two TMSs, one N-terminal and one at about residue 120.	Bacteria	Acidobacteriota	UP of Acidobacteriota bacterium (soil metagenome)
1.C.137.2.1	Uncharacterized protein of 263 aas and 1 TMS at the N-terminus of the protein.	Bacteria	Pseudomonadota	UP of Vibrio campbellii
1.C.137.2.2	Uncharacterized protein of 252 aas and 1 N-terminal TMS.	Bacteria	Deferribacterota	UP of Calditerrivibrio nitroreducens
1.C.137.2.3	Uncharacterized protein of 296 aas and 1 N-terminal TMS + two possible TMSs of lesser hydrophobicity.	Bacteria	Planctomycetota	UP of Planctomycetota bacterium
1.C.137.2.4	Uncharacterized protein of 264 aas and possibly 3 TMSs, one N-terminal and two between residues 100 and 145.	Bacteria	Bacteroidota	UP of Cyclobacteriaceae bacterium (bioreactor metagenome)
1.C.137.3.1	Uncharacterized protein of 249 aas and possibly 1 C-terminal TMS.	Bacteria	Bacteroidota	UP of Bacteroidetes bacterium
1.C.137.3.2	Uncharacterized protein of 276 aas and an unknown number of TMSs.	Bacteria	Planctomycetota	UP of Pirellulaceae bacterium (hot springs metagenome)
1.C.137.3.3	Uncharacterized protein of 276 aas and possibly three moderately hydrophobic TMSs at residues 90, 160 and 230.	Bacteria	Bacteroidota	UP of Bacteroidetes bacterium (phycosphere metagenome)
1.C.137.4.1	Uncharacterized protein of 282 aas and possibly 1 C-terminal TMS.	Bacteria	Bacteroidota	UP of Sphingobacteriales bacterium
1.C.137.4.2	Uncharacterized protein of 264 aas and possibly 2 TMSs between residues 10 and 50. This protein shows sequence similarity between subfamilies 1 and 3 in family 1.C.137.	Bacteria	Bacteroidota	UP of Chitinophagales bacterium
1.C.137.5.1	Uncharacterized protein of 263 aas and 1 or 2 TMSs.	Bacteria	Myxococcota	UP of Nannocystis sp. SCPEA4
1.C.137.5.2	Uncharacterized protein of 257 aas and possibly 1, 2, or 3 TMSs, one N-terminal and two between residues 75 and 110. This protein shows appreciable sequence similarity with members of TC subfamily 1.C.137.1.	Bacteria	Planctomycetota	UP of Gemmataceae bacterium
1.C.137.5.3	Uncharacterized protein of 216 aas and possibly 1 N-terminal TMS.	Bacteria	Vulcanimicrobiota	UP of Candidatus Eremiobacteraeota bacterium
1.C.137.5.4	Uncharacterized protein of 272 aas and possibly 1 TMS at about residue 70.	Bacteria	Pseudomonadota	UP of Pseudomonadota bacterium (soil metagenome)
1.C.137.6.1	Uncharacterized protein of 259 aas and possibly 3 TMSs, one N-terminal and two between residues 100 - 140.	Bacteria	Actinomycetota	UP of Kribbella monticola
1.C.137.6.2	Uncharacterized protein of 323 aas with possibly 3 TMSs, one N-terminal, one at residue 80 snf one at residue 160.	Bacteria	Bacillota	UP of Acetobacterium sp.
1.C.137.6.3	Uncharacterized protein of 250 aas and possibly 3 TMSs in the N-terminal half of the protein.	Bacteria	Actinomycetota	UP of Streptomyces sp.