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Defensin 1, 2 and 3 precursor, also called human neutrophil peptide.

Accession Number:P59665
Protein Name:Neutrophil defensin 1 aka DEFA1
Molecular Weight:10201.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Secreted1
Substrate molecule, water, polyelectrolyte macromolecule

Cross database links:

RefSeq: NP_001035965.1    NP_004075.1   
Entrez Gene ID: 1667    728358   
Pfam: PF00323    PF00879   
OMIM: 125220  gene
KEGG: hsa:1667    hsa:728358   

Gene Ontology

GO:0005615 C:extracellular space
GO:0006935 P:chemotaxis
GO:0042742 P:defense response to bacterium
GO:0050832 P:defense response to fungus
GO:0006955 P:immune response
GO:0031640 P:killing of cells of another organism
GO:0009615 P:response to virus

References (17)

[1] “Isolation and characterization of human defensin cDNA clones.”  Daher   3174637
[2] “A myeloid-related sequence that localizes to human chromosome 8q21.1-22.”  Mars   3370315
[3] “Differentiation stage-specific expression of a gene during granulopoiesis.”  Wiedemann   2918759
[4] “Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3.”  Mars   8530462
[5] “The structure of neutrophil defensin genes.”  Linzmeier   8477861
[6] “”  Linzmeier   8325384
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project   15489334
[8] “Primary structures of three human neutrophil defensins.”  Selsted   4056036
[9] “Signal peptide prediction based on analysis of experimentally verified cleavage sites.”  Zhang   15340161
[10] “Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide.”  Selsted   2917986
[11] “The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells.”  Bateman   2019582
[12] “Posttranslational processing of defensins in immature human myeloid cells.”  Valore   1339298
[13] “Antibacterial activity and specificity of the six human alpha-defensins.”  Ericksen   15616305
[14] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova   18083107
[15] “NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1.”  Zhang   1445872
[16] “NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1.”  Pardi   1445873
[17] “Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.”  Zou   17452329
2KHT   2PM1   3GNY   3H6C   3HJ2   3HJD   3LO1   3LO2   3LO4   3LO6   [...more]

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