TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.21.1.1









Class I lantibiotic bacteriocin Lacticin 481
Bacteria
Bacillota
Lacticin 481 of Lactococcus lactis
1.C.21.1.2









Class I lantibiotic bacteriocin Variacin precursor
Bacteria
Actinomycetota
Variacin of Micrococcus varians
1.C.21.1.3









Class I lantibiotic bacteriocin Streptococcin A-M29 precursor
Bacteria
Bacillota
Streptococcin A of Streptococcus pyogenes
1.C.21.1.4









Class I lantibiotic bacteriocin Salivaricin A precursor
Bacteria
Bacillota
Salivaricin A precursor of Streptococcus salivarius
1.C.21.1.5









Nukacin ISK-1 of 57 aas (Okuda et al., 2008). It is active on Gram-positive bacteria, including Lactobacillus sakei, Leuconostoc mesenteroides and Pediococcus pentosaceus. The bactericidal activity is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores (Aso et al. 2004). It is processed and secreted by NukT (TC# 3.A.1.111.7) (Zheng et al. 2017).

Bacteria
Bacillota
Nukacin ISK-1 of Staphylococcus warneri (Q9KWM4)
1.C.21.1.6









Cyclic bacteriocin, Group II, Butyrivibriocin ARIO (BviA; 80 aas)

Bacteria
Bacillota
BviA of Butyrivibrio fibrisolvens (Q99Q15)
1.C.21.1.7









Salivaricin 9 (SivA; 56 aas; 1 or 2 TMSs) (Wescombe et al., 2011)

Bacteria
Bacillota
SivA of Strepococcus salivarius (Q09I51)
1.C.21.1.8









Lantibiotic nukacin (Nukacin KQ-1) (Nukacin KQU-131)
Bacteria
Bacillota
nukA of Staphylococcus hominis
1.C.21.1.9









Macedocin, McdA1, a pore-forming lantibiotic of 53 aas

Bacteria
Bacillota
Macedocin of Streptococcus macedonicus
1.C.21.1.10









Mutacin II (Mutacin-2) of 53 aas.  It dissipates the pmf and the H+ gradient and interfers with energy metabolism (Chikindas et al. 1995).

Bacteria
Bacillota
Mutacin-2 of Streptococcus mutans
1.C.21.2.1









Putative lantibiotic bacteriocin precursor of 71 aas (van Heel et al. 2013).

Bacteria
Bacillota
Bacteriocin of Streptococcus pneumoniae
1.C.21.2.2









Lichenicidin prepeptide, LanA of 68 aas

Bacteria
Bacillota
Lichenicidin of Bacillus licheniformis
1.C.21.2.3









Lantibiotic, mersacidin, of 69 aas

Bacteria
Bacillota
Mersacidin of Bacillus halodurans
1.C.21.2.4









Two component Lacticin 3147 (Ltnα of 59 aas and Ltnβ of 65 aas (Draper et al. 2015).  Lacticin 3147 and other lantibiotics target Lipid II to inhibit cell wall synthesis, and then form pores in the membrane (Biswas and Biswas 2014).  They target a large number of bacteria, and several mechanisms of pore-formation have been proposed (Draper et al. 2015).

Bacteria
Bacillota
Lactincin 3147 of Streptococcus mutans
1.C.21.2.5









Uncharacterized protein of 55 aas

Bacteria
Bacillota
UP of Clostridium saccharobutylicum
1.C.21.2.6









Lantibiotic, mersacadin, MrsA, of 58 aa

Bacteria
Bacillota
MrsA of Bacillus subtilis
1.C.21.2.7









Uncharacterized protein of 72 aas and 1 TMS. Shows sequence similarity with members of both lantibiotic families, 1.C.21 and 1.C.60.

Bacteria
Bacillota
UP of Lentibacillus amyloliquefaciens