TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.C.21.1.1 | Class I lantibiotic bacteriocin Lacticin 481 | Bacteria |
Bacillota | Lacticin 481 of Lactococcus lactis |
1.C.21.1.2 | Class I lantibiotic bacteriocin Variacin precursor | Bacteria |
Actinomycetota | Variacin of Micrococcus varians |
1.C.21.1.3 | Class I lantibiotic bacteriocin Streptococcin A-M29 precursor | Bacteria |
Bacillota | Streptococcin A of Streptococcus pyogenes |
1.C.21.1.4 | Class I lantibiotic bacteriocin Salivaricin A precursor | Bacteria |
Bacillota | Salivaricin A precursor of Streptococcus salivarius |
1.C.21.1.5 | Nukacin ISK-1 of 57 aas (Okuda et al., 2008). It is active on Gram-positive bacteria, including Lactobacillus sakei, Leuconostoc mesenteroides and Pediococcus
pentosaceus. The bactericidal activity is based on
depolarization of energized bacterial cytoplasmic membranes, initiated
by the formation of aqueous transmembrane pores (Aso et al. 2004). It is processed and secreted by NukT (TC# 3.A.1.111.7) (Zheng et al. 2017). | Bacteria |
Bacillota | Nukacin ISK-1 of Staphylococcus warneri (Q9KWM4) |
1.C.21.1.6 | Cyclic bacteriocin, Group II, Butyrivibriocin ARIO (BviA; 80 aas) | Bacteria |
Bacillota | BviA of Butyrivibrio fibrisolvens (Q99Q15) |
1.C.21.1.7 | Salivaricin 9 (SivA; 56 aas; 1 or 2 TMSs) (Wescombe et al., 2011) | Bacteria |
Bacillota | SivA of Strepococcus salivarius (Q09I51) |
1.C.21.1.8 | Lantibiotic nukacin (Nukacin KQ-1) (Nukacin KQU-131) | Bacteria |
Bacillota | nukA of Staphylococcus hominis |
1.C.21.1.9 | Macedocin, McdA1, a pore-forming lantibiotic of 53 aas | Bacteria |
Bacillota | Macedocin of Streptococcus macedonicus |
1.C.21.1.10 | Mutacin II (Mutacin-2) of 53 aas. It dissipates the pmf and the H+ gradient and interfers with energy metabolism (Chikindas et al. 1995). | Bacteria |
Bacillota | Mutacin-2 of Streptococcus mutans |
1.C.21.2.1 | Putative lantibiotic bacteriocin precursor of 71 aas (van Heel et al. 2013). | Bacteria |
Bacillota | Bacteriocin of Streptococcus pneumoniae |
1.C.21.2.2 | Lichenicidin prepeptide, LanA of 68 aas | Bacteria |
Bacillota | Lichenicidin of Bacillus licheniformis |
1.C.21.2.3 | Lantibiotic, mersacidin, of 69 aas | Bacteria |
Bacillota | Mersacidin of Bacillus halodurans |
1.C.21.2.4 | Two component Lacticin 3147 (Ltnα of 59 aas and Ltnβ of 65 aas (Draper et al. 2015). Lacticin 3147 and other lantibiotics target Lipid II to inhibit cell wall synthesis, and then form pores in the membrane (Biswas and Biswas 2014). They target a large number of bacteria, and several mechanisms of pore-formation have been proposed (Draper et al. 2015). | Bacteria |
Bacillota | Lactincin 3147 of Streptococcus mutans |
1.C.21.2.5 | Uncharacterized protein of 55 aas | Bacteria |
Bacillota | UP of Clostridium saccharobutylicum |
1.C.21.2.6 | Lantibiotic, mersacadin, MrsA, of 58 aa | Bacteria |
Bacillota | MrsA of Bacillus subtilis |
1.C.21.2.7 | Uncharacterized protein of 72 aas and 1 TMS. Shows sequence similarity with members of both lantibiotic families, 1.C.21 and 1.C.60. | Bacteria |
Bacillota | UP of Lentibacillus amyloliquefaciens |