TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.24.1.1









Class IIa bacteriocin Pediocin PA-1 precursor of 62 aas.  Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. The specific receptor acts as a docking molecule, not as a structural piece of the pore, if the bacteriocin is anchored to the membrane (Ríos Colombo et al. 2019).

Bacteria
Firmicutes
Pediocin PA-1 precursor of Pediococcus acidilactici
1.C.24.1.2









Class IIa bacteriocin Sakacin P precursor
Bacteria
Firmicutes
Sakacin P of Lactobacillus sake
1.C.24.1.3









Class IIa bacteriocin Pisciolin 126 precursor
Bacteria
Firmicutes
Pisciolin 126 precursor of Carnobacterium piscicola
1.C.24.1.4









Class IIa bacteriocin Enterocin A
Bacteria
Firmicutes
Enterocin A of Enterococcus faecium
1.C.24.1.5









Class IIa bacteriocin Mesentericin Y105 precursor
Bacteria
Firmicutes
Mesentericin Y105 precursor of Leuconostoc mesenteroides
1.C.24.1.6









Class IIa bacteriocin Leucocin A precursor
Bacteria
Firmicutes
Leucocin A precursor of Leuconostoc gelidum
1.C.24.1.7









Class IIa bacteriocin Carno(bacterio)cin B2 precursor
Bacteria
Firmicutes
Carnocin B2 of Carnobacterium piscicola
1.C.24.1.8









Class IIa bacteriocin Sakacin A precursor (Identical to Curvacin A of Lactobacillus curvatus; P0A311) (Haugen et al. 2008).
Bacteria
Firmicutes
Sakacin A precursor of Lactobacillus sakei ( P0A310)
1.C.24.1.9









Class IIa bacteriocin Bavaricin MN precursor
Bacteria
Firmicutes
Bavaricin MN of Lactobacillus sakei
1.C.24.1.10









Class IIc sec-secreted bacteriocin Enterocin P precursor, EntP
Bacteria
Firmicutes
EntP of Enterococcus faecium
1.C.24.1.11









Class IIa bacteriocin, Ubericin A (Heng et al., 2007)
Bacteria
Firmicutes
Ubericin A of Streptococcus uberis (A9Q0M7)
1.C.24.1.12









Bacteriocin 41 precursor, BacA (pore-forming ability not demonstrated; Tomita et al., 2008)
Bacteria
Firmicutes
BacA of Enterococcus faecalis (B1NRV2)
1.C.24.1.13









Divergicin M35 (43aas) (Naghmouchi et al., 2008) (The C-terminal residues most resemble BacA (TC#1.C.24.1.12)).
Bacteria
Firmicutes
Divergicin M35 of Carnobacterium divergens (P84962)
1.C.24.1.14









Listeria-active class IIa peptide, Lactococcin MMFII (may form pores in lipid bilayers, but also in combination with proteins of the mannose phosphotransferase system (PTS)) (Ferchichi et al., 2001).
Bacteria
Firmicutes
Loctococcin MMFII of Lactococcus lactis (P83002)
1.C.24.1.15









Enterocin CRL35 of 58 aas, MunA. Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. The specific receptor acts as a docking molecule, not as a structural part of the pore, but the bacteriocin must be anchored to the membrane (Ríos Colombo et al. 2019).  The ABC efflux porter is MunB (TC# 3.A.1.112.11).  The enterocin CR35 immunity protein is MunC (98 aas; possibly 2 TMSs; Q6TGQ5).

Bacteria
Firmicutes
Enterocin ARL35 of Enterococcus mundtii
1.C.24.1.16









Uncharacterized protein of 70 aas and 2 TMSs.

Bacteria
Chlamydiae
UP of Chlamydia trachomatis