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1.C.39.2.1 Perforin 1 precursor; targets viruses, bacteria and cancer cells (McCormack et al. 2013). It is produced by cytotoxic T lymphocytes and natural killer cells and has been expressed, purified and studied in insect cells (Naneh et al. 2015).
Accession Number:	P35763
Protein Name:	PERF aka PRF1 aka PFP
Length:	554
Molecular Weight:	61513.00
Species:	Rattus norvegicus (Rat) [10116]
Location¹ / Topology² / Orientation³:	Cytoplasmic granule lumen¹ / Multi-pass membrane protein²
Substrate	molecule

Pfam:	PF00168 PF01823
Gene Ontology GO:0005829 C:cytosol GO:0005576 C:extracellular region GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0007623 P:circadian rhythm GO:0019835 P:cytolysis GO:0045471 P:response to ethanol
References (1) [1] “Molecular cloning of rat cytolysin.” Ishikawa H.et.al. 2809217

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAAYLFLLGL FLLLPRPVPA PCYTATRSEC KQNHKFVPGV WAAGEGVDVT TLRRSSSFPV 
61:	NTGKFLRPDR TCTLCKNALM NDGIQRLPVA IAHWRPHGSH CQRNVATTKV SSTEGVAREA 
121:	AANINNDWRA GLDVNPKPEA NVHVSVAGSH SKIANFAAEK AHQDQYNFNT DTVECRMYSF 
181:	RLAQKPPLHP DFRKALKNLP HNFNSSTEHA YRRLISSYGT HFITAVDLGG RVSVLTALRT 
241:	CQLTLDGLTA DEVGDCLSVE AQVSIGAQAS VSSEYKACEE KKKQHKIATS FHQTYRERHV 
301:	EVLGGPLDSS NDLLFGNQAT PEHFSTWIAS LPTRPDVVDY SLEPLHILLE DSDPKREALR 
361:	QAISHYVMSR ARWRDCNRPC RAGQHKSSRD SCQCVCQDSN VTNQDCCPRQ RGLAKLMVRN 
421:	FQAKGLWGDY ITSTDAYLKV FFGGQEIRTG VVWNNNHPSW SDKMDFGNVL LSTGGPLRVQ 
481:	VWDADNGWDD DLLGTCDKSP KSGFHEVNCP LNHGSIKFIY QANCLPDLTG ETCLEYAPQG 
541:	LLGDPRGNRS GAVW

1.C.39.2.1
Perforin 1 precursor; targets viruses, bacteria and cancer cells (McCormack et al. 2013). It is produced by cytotoxic T lymphocytes and natural killer cells and has been expressed, purified and studied in insect cells (Naneh et al. 2015).

Cross database links:

Gene Ontology

References (1)

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1.C.39.2.1Perforin 1 precursor; targets viruses, bacteria and cancer cells (McCormack et al. 2013). It is produced by cytotoxic T lymphocytes and natural killer cells and has been expressed, purified and studied in insect cells (Naneh et al. 2015).

Cross database links:

Gene Ontology

References (1)

External Searches:

Analyze:

1.C.39.2.1
Perforin 1 precursor; targets viruses, bacteria and cancer cells (McCormack et al. 2013). It is produced by cytotoxic T lymphocytes and natural killer cells and has been expressed, purified and studied in insect cells (Naneh et al. 2015).