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1.C.4.2.1 α-Toxin forms large ion permeable (slightly anion-selective) pores with no lipid specificity. It induces rapid cell necrosis in many cell types (Knapp et al., 2009). The structure of the membrane-spanning domain has been solved (Melton et al. 2004).
Accession Number:	Q53482
Protein Name:	Alpha-toxin
Length:	443
Molecular Weight:	49786.00
Species:	Clostridium septicum [1504]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Secreted¹
Substrate	lipids, small molecules, ions

Pfam:	PF01117
Gene Ontology GO:0005576 C:extracellular region GO:0009405 P:pathogenesis
References (2) [1] “The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin.” Ballard J.et.al. 7806374 [2] “Cloning, nucleotide sequence and expression of a hemolysin gene of Clostridium septicum.” Imagawa T.et.al. 8200504

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FASTA formatted sequence

1:	MSKKSFAKKV ICTSMIAIQC AAVVPHVQAY ALTNLEEGGY ANHNNASSIK IFGYEDNEDL 
61:	KAKIIQDPEF IRNWANVAHS LGFGWCGGTA NPNVGQGFEF KREVGAGGKV SYLLSARYNP 
121:	NDPYASGYRA KDRLSMKISN VRFVIDNDSI KLGTPKVKKL APLNSASFDL INESKTESKL 
181:	SKTFNYTTSK TVSKTDNFKF GEKIGVKTSF KVGLEAIADS KVETSFEFNA EQGWSNTNST 
241:	TETKQESTTY TATVSPQTKK RLFLDVLGSQ IDIPYEGKIY MEYDIELMGF LRYTGNARED 
301:	HTEDRPTVKL KFGKNGMSAE EHLKDLYSHK NINGYSEWDW KWVDEKFGYL FKNSYDALTS 
361:	RKLGGIIKGS FTNINGTKIV IREGKEIPLP DKKRRGKRSV DSLDARLQNE GIRIENIETQ 
421:	DVPGFRLNSI TYNDKKLILI NNI

1.C.4.2.1
α-Toxin forms large ion permeable (slightly anion-selective) pores with no lipid specificity. It induces rapid cell necrosis in many cell types (Knapp et al., 2009). The structure of the membrane-spanning domain has been solved (Melton et al. 2004).

Cross database links:

Gene Ontology

References (2)

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1.C.4.2.1α-Toxin forms large ion permeable (slightly anion-selective) pores with no lipid specificity. It induces rapid cell necrosis in many cell types (Knapp et al., 2009). The structure of the membrane-spanning domain has been solved (Melton et al. 2004).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

1.C.4.2.1
α-Toxin forms large ion permeable (slightly anion-selective) pores with no lipid specificity. It induces rapid cell necrosis in many cell types (Knapp et al., 2009). The structure of the membrane-spanning domain has been solved (Melton et al. 2004).