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Accession Number: | P23907 |
Protein Name: | PRIO aka PrP aka PRNP |
Length: | 256 |
Molecular Weight: | 27915.00 |
Species: | Ovis aries (Sheep) [9940] |
Number of TMSs: | 3 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Lipid-anchor2 |
Substrate | ion |
Cross database links:
RefSeq: | NP_001009481.1 |
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Entrez Gene ID: | 493887 |
Gene Ontology
GO:0031225
C:anchored to membrane
GO:0005794
C:Golgi apparatus
GO:0005886
C:plasma membrane
GO:0008017
F:microtubule binding
GO:0051260
P:protein homooligomerization
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References (14)[1] “Two alleles of a neural protein gene linked to scrapie in sheep.” Goldmann W.et.al. 1969635 [2] “Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.” Westaway D.et.al. 7926780 [3] “Complete genomic sequence and analysis of the prion protein gene region from three mammalian species.” Lee I.Y.et.al. 9799790 [4] “PrP (prion) gene expression in sheep may be modulated by alternative polyadenylation of its messenger RNA.” Goldmann W.et.al. 10466827 [5] “Identification of a novel ovine PrP polymorphism and scrapie-resistant genotypes for St. Croix White and a related composite breed.” Seabury C.M.et.al. 14970684 [6] “Prion protein gene polymorphisms in healthy and scrapie affected sheep in Greece.” Billinis C.et.al. 14769911 [7] “The epididymal soluble prion protein forms a high-molecular-mass complex in association with hydrophobic proteins.” Ecroyd H.et.al. 16029166 [8] “The crystal structure of the globular domain of sheep prion protein.” Haire L.F.et.al. 15037077 [9] “Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.” Eghiaian F.et.al. 15240887 [10] “Prion protein NMR structures of cats, dogs, pigs, and sheep.” Lysek D.A.et.al. 15647367 [11] “Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene.” Goldmann W.et.al. 1681027 [12] “PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis.” Laplanche J.-L.et.al. 8094373 | |
Structure: | |
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MVKSHIGSWI LVLFVAMWSD VGLCKKRPKP GGGWNTGGSR YPGQGSPGGN RYPPQGGGGW 61: GQPHGGGWGQ PHGGGWGQPH GGGWGQPHGG GGWGQGGSHS QWNKPSKPKT NMKHVAGAAA 121: AGAVVGGLGG YMLGSAMSRP LIHFGNDYED RYYRENMYRY PNQVYYRPVD RYSNQNNFVH 181: DCVNITVKQH TVTTTTKGEN FTETDIKIME RVVEQMCITQ YQRESQAYYQ RGASVILFSS 241: PPVILLISFL IFLIVG