1.C.57.3.4
RTX (repeat in toxin) cytotoxin of 5206 aas, also called the "multifunctional-autoprocessing RTX" (MARTXVv) toxin, or Vibrio vulnificus cytotoxin (VVC). It exists in at least four distinct variants of the rtxA1 gene that encode toxins with different arrangements of effector domains that arose by recombination. VVC, in addition to being a pore-forming toxin, may be a transmembrane toxin with the ability to induce
apoptosis in human vascular endothelial cells and tumor cells (Zhao et al. 2009). The protein has an α,β-hydrolase domain (residues ~2900 - 3120).
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| Accession Number: | Q7MDK6 |
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| Protein Name: | RTX (Repeat in toxin) cytotoxin |
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| Length: | 5206 |
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| Molecular Weight: | 556209.00 |
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| Species: | Vibrio vulnificus (strain YJ016) [196600] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 / Single-pass membrane protein2 |
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| Substrate |
peptides, small molecules |
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1: MGKPFWRSVE YFFTGNYSAD DGNNSIVAIG FGGEIHAYGG DDHVTVGSIG ATVYTGSGND
61: TVVGGSAYLR VEDTTGHLSV KGAAGYADIN KSGDGNVSFA GAAGGVSIDH LGNHGDVSYG
121: GAAAYNGITR KGLSGNVTFK GAGGYNALWH ETNQGNLSFA GAGAGNKLDR TWFNRYQGSR
181: GDVTFDGAGA ANSISSRVET GNITFRGAGA DNHLVRKGKV GDITLQGAGA SNRIERTRQA
241: EDVYAQTRGN IRFEGVGGYN SLYSDVAHGD IHFSGGGAYN TITRKGSGSS FDAQGMEYAK
301: AEDIVLTAAQ MHGLSIDNGN KFHAVTAVKS EREPNTYLFA IADGTYTKIN KVRLYNDPET
361: GKLKYYSEAW FKRGNHLAEL ARSDVSSAGG FEVNPINGGY TLSNIAVEHQ QSLTVHAVEK
421: DLTEYEWVTY ANGALIDAKD VALSEAKMGG HAISTDGTTV DVQAVKSNRK PNTYVYAKVL
481: GPYTKIVVVE LANDPKTGAL KYQARSWYKE GNHTANLANE DISSANGYHS MGKGGYSLSD
541: LHYSVNAVRS TSETVADIDE YTDQTLFKPA TDSGESSGDV RFNGAGGGNV IKSNVTRGNV
601: YFNGGGIANV ILHSSQFGHT EFNGGGAANV IVKSGEEGDL TFRGAGLANV LVHQSKQGKM
661: DVYAGGAVNV LVRIGDGQYL AHLLAYGNIS VHKGNGNSRV VMLGGYNTHT QIGSGNGLWL
721: AAGGFNVMTQ VGKGDVASVL AGGANVLTKV GDGDLTAGML GGANVITHIS GDNETSNTTA
781: VALGGANILT KKGKGNTLAV MGGGANVLTH VGDGTTTGVM VGGANILTKV GNGDTTGIML
841: GVGNVLTHVG DGQTLGVMGA AGNIFTKVGD GTSIAVMIGA GNIFTHVGEG NAWALMGGLG
901: NVFTKVGNGD ALALMVAEAN VFTHIGDGMS VALMLAKGNV ATKVGNGTTL AAMVGNANIF
961: THVGSGSTFA AMIGQANIMT KVGNDLTAAL MVGKANIYTH VGDGTSLGIF AGEVNVITKV
1021: GNGTTLAAMF GKANIMTHVG DGLTGVLALG EANIVTKVGD DFMGVVAAAK ANVVTHVGDA
1081: TTAAVLAGKG NILTKVGEGT TVGLLISDIG NVMTHVGDGT TIGIAKGKAN IITKVGDGLG
1141: VNVAWGQANV FTQVGDGDRY NFAKGEANII TKVGDGQEVS VVQGKANIIT HVGNGDDYTG
1201: AWGKANVITK VGNGRNVVLA KGEANIVTQV GDGDSFNALW SKGNIVTKVG DGMQVTAAKG
1261: KANITTTVGD GLSVTAAYGD ANINTKVGDG VSVNVAWGKY NINTKVGDGL NVAVMKGKAN
1321: ANIHVGDGLN INASYAQNNV AIKVGNGDFY SLAVASSNTS SNKLSALFDN IKQTLLGVGG
1381: SQAINYLVQG DEASSSGTQK GRGAIATPEI TKLDGFQMEA IEEVGSDLGD SLTGSVTKVD
1441: TPDLNKMQNA LDVDGSADQT QAPNLIVNGD FEQGDRGWKS THGVEASYSG NVYGVNGEGH
1501: GARVTELDTY TNTSLYQDLT DLTEGEVIAV SFDFAKRAGL SNNEGIEVLW NGEVVFSSSG
1561: DASAWQQKTL KLTAHAGSNR IEFKGTGHND GLGYILDNVV AKSESSQQAN AVSEHATQNQ
1621: ASQNALSDKE CAEADRQRLE QEKQKQLDAV AGSQSQLEST DQQALENNGQ AQRDAVKEES
1681: EAVTAELTKL AQGLDVLDGQ ATHTGESGDQ WRNDFAGGLL DGVQSQLDDA KQLANDKIAA
1741: AKQTQSDNNS KVKESVAKSE AGVAKGEQNR AGAEQDIAEA KADAETRKAD AVAKSNDAKQ
1801: AESDAHSAAN DAQSRGDRDA MNAENKANQA QNDAKGTKQN EGDRPDREGV AGSGLSGNAH
1861: SVEGAGETGS HVNTDSPTNA DGRFSEGLSE QEQEALEGAT NAVNRLQINA GIRGKNSGST
1921: ITSMFTETNS DSIVVPTTAS QDVVRQEIRI SGVNLEGLGE TSHDSAESLV AARAEKVANL
1981: YRWLDTDNDV ATDKYVPVPG FERVDADVSD EVKQRMIQSM SGYIEHTDNQ VPKDQAEALA
2041: TLFVESTLDY DWDKRVEFLT KLESYGYSFE APHAEKSIVS FWSGKNFKQY RDVLDNAQTD
2101: GKKVVYDIDV KGNAFAIDLN KHLMRWGGLF LDPDNAEQNQ LKSSIDAATF SNTGFWSSVY
2161: ATGAQNDVYV IAEGGVRLGN YFWNVELPAL RQLQREGLVG EIRLLDKPVS EYKDLPADQI
2221: GRRLTDAGVA VKVRFDALSH ERQAELLADN PDGYKADTLV ELDVKLSAID SMLRESLPFY
2281: SLRTERNLLV QEGEEGFEVR SWPGIDGKSK TILLDNPEDA AQQKSIERFI LANFDNFEQM
2341: PDELFLVDNK VLSHHDGRTR IIAQKEDGAW TYNTNVELMS VTELLDAAHV NGKVRGDSYQ
2401: QVIDALTEYH ASTVEHADYE LESVEKLLNL RKQIEGYVLG HPDSGRVEAM NSLLNQVNSR
2461: LEEVSVLAVS EQSIKAHDSF SRLYDQLDNA NLKESKHLYL DGNGDFVTKG KGNLATIDQL
2521: GGSDAVLEKV KAAVTHEYGQ VVADTIFAGL SANDLAKDGK GIDIAGLNKV HQAIEQHMSP
2581: VSATMYIWKP SDHSALGHAA LQIGQGRTQL EGQAAADFNK QNYVSWWPLG SKSSNIRNIF
2641: NVATEDQPDL KLRWSDFSQP AHQNDTLEHD MASEENDGFG LKDGETKLKR FIEKLNAAKG
2701: IDASYKDASE GYASVLLGNP DMLASTGIPA HVFQPFVDQW NDTSYDMMDV ANRFAEELQK
2761: QAQASGDPAL VEKRIDNVVR LFAERALEEI EAFKASQADE GRVFRINLEG LDVAAMQAEW
2821: NRLSNDPDAR YQLLTKNCSS TVAKVLKAGG ADKLIGHTWR PKFGVWTPTE LFNFGQALQE
2881: AQLEIAAKKQ SHQVTDVLDA LSGNEKHKEN VAIENDGTPP RDKESLSPLT RFLNNELYGE
2941: KDARRKIGEI TQTLLDHAVE NGESQKVTLK GEVGRLTGYY HQGAASSEGE TSATSGKVVL
3001: FLHGSGSSAE EQASEIRNHY QKQGIDMLAV NLRGYGESDG GPSEKGLYQD ARTMFNYLVN
3061: DKGIDPSNII IHGYSMGGPI AADLARYAAQ NGQAVSGLLL DRPMPSMTKA ITAHEMANPA
3121: GIVGAIAKAV NGQFSVEKNL KGLPKETPIL LLTDNEGLGE EGEKLRAKLA IAGYNVTGEQ
3181: TFYGHEASNR LMGQYADQIV SGLFNAEQAA VEAGEVLKGL EKDFKRYGDA LKPDTSVPGK
3241: SKDIRTTKDF LNGYKNDHAK EIVDGFRSDM SIKQLVDLFV KGNWSAEQKG ALAWEIESRA
3301: LKVTFQNKSE KYNRLFREIA SAGVVDAKAT EQLAPQLMLL NLSNDGFGGR CDPLSKLVLV
3361: AKQLENDGQV GVARQLLEKM YSAAAVLSNP TLYSDSEKAN ASKLLSSLAA IHAKNPMHDT
3421: SMKVWQEKLE GKQALTVNGV VEKITDASAN GKPVLLELDA PGHAMAAWAK GSGDDRVYGF
3481: YDPNAGIVEF SSAEKFGDYL TRFFGKSDLN MAQSYKLGKN DAGEAIFNRV VVMDGNTLAS
3541: YKPTFGDKTT MQGILDLPVF DATPIKKPTG GVASDLEALG DKTKVVVDLA QIFTVQELKE
3601: RAKVFAKPIG ASYQGILDQL DLVHQAKGRD QIAASFELNK KINDYIAEHP TSGRNQALTQ
3661: LKKQVTNALF IGKMQVAQAG IDAIAQTRPE LAARIFMVAI EEANGKHVGL TDMMVRWANE
3721: DPYLAPKHGY KGETPSDLGF DAKYHVDLGE HYADFKQWLE TSQSNGLLSK ATLDESTKTV
3781: HLGYSYQELQ DLTGAESVQM AFYFLKEAAK KADPISGDSA EMILLKKYAD QSYLSQLDSD
3841: RMDQIEGIYR SSHETDIDAW DRRYSGTGYD ELTNKLASAT GVDEQLAVLL DDRKGLLIGE
3901: VHGSDVNGLR FVNEQMDALK KQGVTVIGLE HLRSDLAQPL IDRYLATGVM SSELSAMLKT
3961: KHLDVTLFEN ARANGMRIVA LDANSSARPN VQGTEHGLMY RAGAANNIAV EVLQNLPDGE
4021: KFVAIYGKAH LQSHKGIEGF VPGITHRLDL PALKVSDSNE FTVEQDDVSL RVVYDDVANK
4081: PKITFKDSLS GANTALHNQN VNDWERVVVT PTADGGESRF DGQIIVQMEN DDVVAKAAAN
4141: LAGKHPESSV VVQIDSDGNY RVVYGDPSKL DGKLRWQLVG HGRDDSESNN TRLSGYSADE
4201: LAVKLAKFQQ SFNQAENINN KPDHISIVGC SLVSDDKQKG FGHQFINAMD ANGLRVDVSV
4261: RSSELAVDEA GRKHTKDANG DWVQKAENNK VSLSWDEQGE VVAKDERIRN GIAEGDIDLS
4321: RIGVSDVDEP ARGAIGDNND VFDAPEKRKA ETETSSSSAN NKLSYSGNIQ VNVGDGEFTA
4381: VNWGTSNVGI KVGTGGFKSL AFGDNNVMVH IGNGESKHSF DIGGYQALEG AQMFIGNRNV
4441: SFNLGRSNDL IVMMDKSIPT PPLVNPFDGA ARISGVLQSI ATSGEGQDWL AAQEQQWTLS
4501: GAKKFVKDMS GLDQSSSVDY TSLVELDSQN ERSSRGLKHD AEAALNKQYN QWLSGNSDSD
4561: TSKLSRADKL RQANEKLAFN FAVGGQGADI QVTTGNWNFM FGDNIQSILD TNLGSLFGLM
4621: TQQFSATGQA KTTFTYTPED LPRQLKNKLL GQLAGVGAET TLADIFGVDY TASGQIVSRN
4681: GEAVDGVAIL KEMLEVIGEF SGDQLQAFVD PAKLLDSLKA GINMGADGIK SFAETHGLKE
4741: KAPEEEEDNS SVSVNGASVN SAQGATVADG STETAETPDR AFGFNSLNLP NLFATIFSQD
4801: KQKEMKSLVE NLKENLTADL LNMKEKTFDF LRNSGHLQGD GDINISLGNY NFNWGGDGKD
4861: LGAYLGDNNN FWGGRGDDVF YATGTSNIFT GGEGNDMGVL MGRENMMFGG DGNDTAVVAG
4921: RINHVFLGAG DDQSFVFGEG GEIDTGSGRD YVVTSGNFNR VDTGDDQDYS VTIGNNNQVE
4981: LGAGNDFANV FGNYNRINAS AGNDVVKLMG YHAVLNGGEG EDHLIAAAIS KFSQFNGGEG
5041: RDLMVLGGYQ NTFKGGTDVD SFVVSGDVID NLVEDIRSED NIVFNGIDWQ KLWFERSGYD
5101: LKLSILRDPA SDSDQAKFEH IGSVTFSDYF NGNRAQVIIA MGEKDATGER EYTTLSESAI
5161: DALVQAMSGF DPQAGDNGFI DNLDSKSRVA ITTAWADVVH KKGITV