TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.73.1.1









Pore-forming exotoxin A (chain A; ExlA)  (Rasper and Merrill 1994; Méré et al., 2005).  Pore-formation has been demonstrated (Zalman and Wisnieski 1985).  Secretion depends on ExlB, a Two Partner Secretion (TPS; TC# 1.B.20) system, as well as type IV pili.  The protein has three domains: an N-terminal hemolyin domain, a central RGD motif domain, and a C-terminal domain required for cell lysis.  Pore-formation precedes lysis (Basso et al. 2017). ExlA triggers cadherin cleavage by promoting calcium influx which activates ADAM10 for proteolysis (Reboud et al. 2017).

Bacteria
Pseudomonadota
Exotoxin A (ExlA) of Pseudomonas aeruginosa (P11439)
1.C.73.1.2









The cholix toxin.  The NAD-dependent ADP-ribosyltransferase (ADPRT) catalyzes transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2), thus arresting protein synthesis. It may use the eukaryotic pro-low-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells,  Cholix toxin shares structural and functional properties with Pseudomonas aeruginosa exotoxin A and Corynebacterium diphtheriae diphtheria toxin (Lugo and Merrill 2015).

Bacteria
Pseudomonadota
Cholix toxin of Vibrio cholera
1.C.73.1.3









Exotoxin A of 241 aas

Bacteria
Myxococcota
Exotoxin A of Cystobacter fuscus
1.C.73.2.1









Uncharacterzed protein of 679 aas

Bacteria
Pseudomonadota
UP of Yersinia frederiksenii
1.C.73.2.2









Exotoxin of 806 aas

Bacteria
Pseudomonadota
Exotoxin of Yersinia similis
1.C.73.3.1









Uncharacterized protein of 698 aas

Bacteria
Actinomycetota
UP of Mycobacterium gastri
1.C.73.3.2









Uncharacterized toxin of 736 aas.

Bacteria
Acidobacteriota
Toxin of Chloracidobacterium thermophilum
1.C.73.3.3









Putative toxin of 937 aa

Bacteria
Planctomycetota
Toxin of Blastopirellula marina
1.C.73.3.4









Putative toxin of 679 aas

Bacteria
Cyanobacteriota
Toxin of Gloeocapsa sp. PCC 7428