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1.C.74.1.1
Cobra cardiotoxin-1 (cytotoxin CM-6), CTX1. It is a basic protein that binds to cell membranes and depolarizes cardiomyocytes. It also possesses lytic activity on many cells, including red blood cells (Chien et al. 1994). Cytotoxicity is due to pore formation and to another mechanism independent of membrane-damaging activity (Wang et al. 2006).

Accession Number:P60305
Protein Name:CTX1 aka Cytotoxin 1
Length:60
Molecular Weight:6701.00
Species:Naja kaouthia (Monocled cobra) (Naja siamensis) [8649]
Location1 / Topology2 / Orientation3: Secreted1
Substrate ion, molecule

Cross database links:

Pfam: PF00087   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019835 P:cytolysis
GO:0009405 P:pathogenesis

References (4)

[1] “The complete amino acid sequence of a cardiotoxin from the venom of Naja naja (Cambodian Cobra).”  Fryklund L.et.al.   1148180
[2] “The complete primary structures of three cytotoxins (CM-6, CM-7 and CM-7A) from Naja naja kaouthia (Siamese cobra) snake venom.”  Joubert F.J.et.al.   7210030
[3] “Amino-acid sequences of four cytotoxins (cytotoxins I, II, III and IV) purified from the venom of the Thailand cobra, Naja naja siamensis.”  Ohkura K.et.al.   3365434
[4] “Naturally occurring disulfide-bound dimers of three-fingered toxins: a paradigm for biological activity diversification.”  Osipov A.V.et.al.   18381281

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FASTA formatted sequence 
1:	LKCNKLIPIA SKTCPAGKNL CYKMFMMSDL TIPVKRGCID VCPKNSLLVK YVCCNTDRCN