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| Accession Number: | P60615 |
| Protein Name: | Alpha-bungarotoxin isoform A31 |
| Length: | 95 |
| Molecular Weight: | 10285.00 |
| Species: | Bungarus multicinctus (Many-banded krait) [8616] |
| Number of TMSs: | 1 |
| Location1 / Topology2 / Orientation3: | Secreted1 |
| Substrate | ion, molecule |
Cross database links:
| Pfam: | PF00087 |
|---|---|
Gene Ontology
GO:0005576
C:extracellular region
GO:0045211
C:postsynaptic membrane
GO:0030550
F:acetylcholine receptor inhibitor activity
GO:0009405
P:pathogenesis
GO:0007268
P:synaptic transmission
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References (21)[1] “Genetic characterization of the mRNAs encoding alpha-bungarotoxin: isoforms and RNA editing in Bungarus multicinctus gland cells.” Liu L.-F.et.al. 9837992 [2] “Genetic organization of alpha-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of alpha-bungarotoxin isotoxins is not derived from edited mRNAs.” Chang L.-S.et.al. 10497260 [3] “Purification, properties and amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus.” Mebs D.et.al. 5027709 [4] “Primary structure of alpha-bungarotoxin. Six amino acid residues differ from the previously reported sequence.” Ohta M.et.al. 3653402 [5] “Isolation of antigenically reactive peptide fragments and localization of antigenic regions of alpha-bungarotoxin.” Chuang L.Y.et.al. 2458724 [6] “Structural studies of alpha-bungarotoxin. 3. Corrections in the primary sequence and X-ray structure and characterization of an isotoxic alpha-bungarotoxin.” Kosen P.A.et.al. 3401449 [7] “Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor.” Servent D.et.al. 9305882 [8] “cDNA sequence analysis and expression of alpha-bungarotoxin from Taiwan banded krait (Bungarus multicinctus).” Kuo K.-W.et.al. 7488184 [9] “Effects of alpha-erabutoxin, alpha-bungarotoxin, alpha-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo.” Dajas-Bailador F.et.al. 9840221 [10] “Neutralizing monoclonal antibody specific for alpha-bungarotoxin: preparation and characterization of the antibody, and localization of antigenic region of alpha-bungarotoxin.” Kase R.et.al. 2476330 [11] “The crystal structure of alpha-bungarotoxin at 2.5-A resolution: relation to solution structure and binding to acetylcholine receptor.” Love R.A.et.al. 3507686 [12] “Structural studies of alpha-bungarotoxin. 1. Sequence-specific 1H NMR resonance assignments.” Basus V.J.et.al. 3401447 [13] “Structural studies of alpha-bungarotoxin. 2. 1H NMR assignments via an improved relayed coherence transfer nuclear overhauser enhancement experiment.” Basus V.J.et.al. 3401448 [14] “NMR solution structure of an alpha-bungarotoxin/nicotinic receptor peptide complex.” Basus V.J.et.al. 8241115 [15] “Three-dimensional solution structure of the complex of alpha-bungarotoxin with a library-derived peptide.” Scherf T.et.al. 9177168 [16] “The solution structure of the complex formed between alpha-bungarotoxin and an 18-mer cognate peptide derived from the alpha 1 subunit of the nicotinic acetylcholine receptor from Torpedo californica.” Zeng H.et.al. 11312275 [17] “The binding site of acetylcholine receptor as visualized in the X-ray structure of a complex between alpha-bungarotoxin and a mimotope peptide.” Harel M.et.al. 11683996 [18] “A beta -hairpin structure in a 13-mer peptide that binds alpha -bungarotoxin with high affinity and neutralizes its toxicity.” Scherf T.et.al. 11381118 [19] “NMR structure of alpha-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor.” Scarselli M.et.al. 11814338 [20] “NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.” Moise L.et.al. 11790782 [21] “The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR.” Samson A.O.et.al. 12160749
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1: MKTLLLTLVV VTIVCLDLGY TIVCHTTATS PISAVTCPPG ENLCYRKMWC DAFCSSRGKV 61: VELGCAATCP SKKPYEEVTC CSTDKCNPHP KQRPG