1.C.74.1.8
Muscarinic toxin MT7 of 88 aas and 1 TMS. Forms a complex with the M1 muscarinic receptor with subnanomorlar affinity with a very slow dissociation rate. The 3-D crystal structure is known and reveals how it inhibits agonist-mediated GTP-γ-S binding and downstream signaling (Maeda et al. 2020).
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| Accession Number: | Q8QGR0 |
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| Protein Name: | Muscarinic toxin 7 |
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| Length: | 86 |
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| Molecular Weight: | 9771.00 |
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| Species: | Dendroaspis angusticeps (Eastern green mamba) [8618] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MKTLLLTLVV VTIVCLDLGY TLTCVKSNSI WFPTSEDCPD GQNLCFKRWQ YISPRMYDFT
61: RGCAATCPKA EYRDVINCCG TDKCNK