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| Accession Number: | P04080 |
| Protein Name: | Cystatin-B |
| Length: | 98 |
| Molecular Weight: | 11140.00 |
| Species: | Homo sapiens (Human) [9606] |
| Location1 / Topology2 / Orientation3: | Cytoplasm1 |
| Substrate | orobol |
Cross database links:
| RefSeq: | NP_000091.1 |
|---|---|
| Entrez Gene ID: | 1476 |
| Pfam: | PF00031 |
| OMIM: |
254800 phenotype 601145 gene |
| KEGG: | hsa:1476 |
Gene Ontology
GO:0005737
C:cytoplasm
GO:0005730
C:nucleolus
GO:0004869
F:cysteine-type endopeptidase inhibitor activity
GO:0002020
F:protease binding
GO:0010466
P:negative regulation of peptidase activity
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References (10)[1] “Amino acid sequence of the intracellular cysteine proteinase inhibitor cystatin B from human liver.” Ritonja A.et.al. 3902020 [2] “Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1).” Pennacchio L.A.et.al. 8596935 [3] “The DNA sequence of human chromosome 21.” Hattori M.et.al. 10830953 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1).” Riccio M.et.al. 11139332 [6] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [7] “An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.” Heibeck T.H.et.al. 19534553 [8] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.” Choudhary C.et.al. 19608861 [9] “The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.” Stubbs M.T.et.al. 2347312 [10] “Identification of mutations in cystatin B, the gene responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1).” Lalioti M.D.et.al. 9012407
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| Structure: | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG 61: DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF