1.C.92.1.3
Neuronal pentraxin receptor-1 (NPR1) of 432 aas and 1 or 2 N-terminal TMSs. May be involved in mediating uptake of
synaptic material during synapse remodeling or in mediating the synaptic
clustering of AMPA glutamate receptors at a subset of excitatory
synapses. NPR is a potent inducer of both excitatory and inhibitory heterologous synapses; knockdown of NPR in cultured neurons decreases the density of both excitatory and inhibitory synapses (Lee et al. 2017). NPR1 is an auxiliary subunit of AMPA receptors (Matthews et al. 2021).
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| Accession Number: | Q15818 |
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| Protein Name: | Neuronal pentraxin-1 |
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| Length: | 432 |
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| Molecular Weight: | 47122.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 |
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| Substrate |
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1: MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG AEELRSSVLQ
61: LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG EARAGGGRKQ PGSGKNTMGD
121: LSRTPAAETL SQLGQTLQSL KTRLENLEQY SRLNSSSQTN SLKDLLQSKI DELERQVLSR
181: VNTLEEGKGG PRNDTEERVK IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY
241: AKVKKSLPEM YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
301: AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ GVLVLGQEQD
361: TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK ALSGNVIAWA ESHIEIYGGA
421: TKWTFEACRQ IN