TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.C.99.1.1









Cation (K+, Na+)-selective pore-forming Orf8a (Sars8a) peptide of 39 aas and 1 N-terminal TMS (Hsu et al. 2015, Scott and Griffin 2015).

Viruses
Orthornavirae, Pisuviricota
Orf8a of severe acute respiratory syndrome causing corona virus (SARS-CoV) (Q7TA23)
1.C.99.1.2









Pore-forming protein of 122 aas with 1 N-terminal TM

Viruses
Orthornavirae, Pisuviricota
Pore-former of Bat β-coronavirus
1.C.99.1.3









Non structural protein 8 of 121 aas and 1 N-terminal TM

Viruses
Orthornavirae, Pisuviricota
Protein 8 of Bat coronavirus 279/2005 (BtCoV)
1.C.99.1.4









ORF8 protein of 121 aas and 1 N-terminal TMS. Orf8 is a short 29-amino-acid single-passage transmembrane peptide that forms cation-selective channels when assembled in lipid bilayers (Barrantes 2021). A cell-based system combined with flow cytometry can be used to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19 (Martin et al. 2022).

Viruses
Orthornavirae, Pisuviricota
ORF8 of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
1.C.99.1.5









Uncharaacterized protein, Sars8b of 84 aas and 0 TMSs.  This protein may be N-terminally truncated.

Viruses
Orthornavirae, Pisuviricota
Sars8b of Severe acute respiratory syndrome-related coronavirus (SARS)
1.C.99.2.1









Uncharacterized protein of 101 aas and 1 or 2 TMSs, with one TMS at the N-terminus, and possibly another at the C-terminus.

Viruses
Orthornavirae, Pisuviricota
UP of SARS coronavirus WH20
1.C.99.2.2









Orf7a of 121 aas and 2 or 3 TMSs, one at the N-terminus, one at the C-terminus, and a peak of moderate hydrophobicity in the middle.  N-terminal fragments of 29 aas, 39 aas and 43 aas can be found in the NCBI protein database (Acc# QIG55990, QIS30140, and QIZ64621, respectively). Bone marrow stromal antigen 2 (BST-2; tetherin) is an antiviral response protein that inhibits transport of viral particles after budding within infected cells. RNA viruses such as SARS-CoV-2 use various strategies to disable BST-2. ORF7a TMS interactions play a key role along with extracellular and juxtamembrane domains in modulating BST-2 function (Mann et al. 2023).

Viruses
Orthornavirae, Pisuviricota
Orf7a of severe acute respiratory syndrome coronavirus 2
1.C.99.2.3









X4-like protein of 120 aas and 2 TMSs, N- and C-terminal.

Viruses
Orthornavirae, Pisuviricota
X4-like protein of Rhinolophus bat coronavirus HKU32