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1.D.122.  The TRP-PK1 Channel, derived from the 4th TMS of TRPV4 (TRP-PK1) Family

A synthetic peptide, the sequence of which was derived from the fourth TMS of TRPV4 (TC# 1.A.4.2.5), was found to be capable of self-assembling into potassium (K+)-like ion channels and was designated TRP-PK1 (Yu et al. 2014).  It formed channels in the membranes of liposomes and live cells. TRP-PK1 effectively mediates K+ flow across membranes to regulate the membrane potential. It is also able to relax agonist-induced vessel contraction and regulate the resting blood pressure by hyperpolarizing the vascular smooth muscle cell membrane potential. TRP-PK1 is a lead compound for mimicking K+ channels and treating hypertension, heart rate disorder and other K+ channel dysfunction-induced diseases.

References associated with 1.D.122 family:

Yu, Z., , J. Li, , J. Zhu, , M. Zhu, , F. Jiang, , J. Zhang, , Z. Li, , M. Zhong, , J.B. Kaye, , J. Du, , and B. Shen,. (2014). A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential. J Mater Chem B 2: 3809-3818. 32261727