1.D.134. The Anti-Fungal Pore-forming Peptide (Bac8c) Family
Bac8c (RIWVIWRR-NH2) is an analogue peptide derived through complete substitution analysis of the linear bovine host defense peptide variant Bac2A. Its antifungal mechanism involveds the cytoplasmic membrane, and it induced disturbances in the membrane potential of Candida albicans. An increase in membrane permeability and suppression of cell wall regeneration were also observed in Bac8c-treated C. albicans. Bac8c has a pore-forming action on fungal membranes, with an estimated pore radius of between 2.3 and 3.3 nm and potassium was released from the cytosol (Lee and Lee 2015).