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1.D.140. The Light-sensitive Supramolecular Anion Channel (L-SMAC) Family 

The design of synthetic supramolecular ion transporters that can be precisely controlled by external signals, in particular, by bio-compatible wavelengths of visible light, is key for achieving spatio-temporal control over function. Kerckhoffs and Langton 2020 reported two-colour responsive molecular photo-switches that act as supramolecular transmembrane anion carriers. Reversible switching of the photo-switch within the lipid bilayer membrane could be achieved using biocompatible visible wavelengths of light, such that temporal control over transmembrane anion transport is achieved through alternating irradiation with red and blue light (Kerckhoffs and Langton 2020).

References associated with 1.D.140 family:

Kerckhoffs, A. and M.J. Langton. (2020). Reversible photo-control over transmembrane anion transport using visible-light responsive supramolecular carriers. Chem Sci 11: 6325-6331. 32953027