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1.D.142.  The Aminoimidazole Amphiphile Channel (AIAC) Family

Amino-imidazole amphiphiles self-assemble via multiple H-bonding to form stable artificial Cl- channels within lipid bilayers (Zheng et al. 2020). The alignment of water/Cl- wires influences the conduction of ions, envisioned to diffuse along the hydrophilic pathways; at acidic pH, Cl- /H+ symport conducts along a partly protonated channel, while at basic pH, higher Cl- /OH- antiport translocates through a neutral channel configuration, which can be greatly activated by applying a strong electric field. This voltage/pH-regulated channel system represents an alternative for ion-pumping via artificial ion-channels, parallel to that of natural biological channel proteins (Zheng et al. 2020).

References associated with 1.D.142 family:

Zheng, S.P., J.J. Jiang, A. van der Lee, and M. Barboiu. (2020). A Voltage-Responsive Synthetic Cl -Channel Regulated by pH. Angew Chem Int Ed Engl. [Epub: Ahead of Print] 32820831