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1.D.163.  The p-Octiphenyl beta-Barrel with LWV Triad (POP-BB) Family 

Pores formed by p-octiphenyl beta-barrels with LWV triads at the outer surface were compared with the conventional rigid-rod beta-barrels with all-L outer surfaces (Talukdar et al. 2004). Tetrameric pores with external LWV triads (inversion of ion selectivity, molecular recognition and transformation) was implicative for an intact barrel interior. Increased pore activity supported dominance of high bilayer affinity for W over low affinity for V. Transmembrane p-octiphenyl orientation (from fluorescence depth quenching) supported barrel-stave (rather than toroidal) pores and dominance of transmembrane preference of rigid rods over interfacial preference of W. Destabilization of beta-barrel pores in membranes (from short single-channel lifetimes) and in the media (from 4th-power dependence on monomer concentration) by LWV triads supported dominance of low beta-propensity for W over high beta-propensity for V. The relation between the stability of supramolecular (pre)pores and dependence of activity on the monomeric concentration was discussed (Talukdar et al. 2004).

References associated with 1.D.163 family:

Talukdar, P., N. Sakai, N. Sordé, D. Gerard, V.M. Cardona, and S. Matile. (2004). Outer surface modification of synthetic multifunctional pores. Bioorg Med Chem 12: 1325-1336. 15018904