1.D.168. The Proton-conducting Quinoline-derived Nanopore (PQNP) Family
A unimolecular transmembrane proton channel can be formed by a quinoline-derived helix, which exhibits highly selective and ultrafast proton transport behavior. This helix-based channel possesses a small luminal cavity of 1 Å in diameter, which can efficiently reject the permeation of cations, anions and water molecules while permiting the translocation of protons due to a size effect. The single proton channel flow rate exceeded 107 H+/sec. Mechanistic investigations revealed that the directionally arrayed NH-chain inside the synthetic channel played a pivotal role during proton fluxes (Yan et al. 2021).