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1.D.197.  The Squaramide-based Anionophore (SbA) Family 

A family of squaramide-based anionophores (L1-L8) has been synthesised and characterized to investigate the effect of indolyl substituents on their anion binding and transmembrane transport properties. L1, L2, L6, and L8, bearing a 7-indolyl/indol-7-yl moiety as the substituent, were found to be the most efficient of the series in binding chloride with high stability constants. L1, L6, and L8 were also found to be the most potent anionophores of the series, able to mediate transmembrane anion transport. In particular, L6, bearing the 3,5-bis(trifluoromethyl)phenyl group, was found to be the most active transporter, and its efficiency as an anionophore/anion transporter was favourably compared with that of their symmetrically-substituted squaramide analogues L9 and L10, previously reported in the literature (Picci et al. 2022).

References associated with 1.D.197 family:

Picci, G., I. Carreira-Barral, D. Alonso-Carrillo, C. Busonera, J. Milia, R. Quesada, and C. Caltagirone. (2022). The role of indolyl substituents in squaramide-based anionophores. Org Biomol Chem 20: 7981-7986. 36196986