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1.D.216.  The 1,2,3-Triazole Group-containing Compound (1,2,3-TGC) Family 

The activities of compounds 69a–d (see below), inspired by the structure of prodigiosin, and including a 1,2,3-triazole group was explored (Hernando et al. 2018).  Iodide transport activity was found to be in the same order as that of the activated CFTR for the most active derivatives 69b,c. These compounds were more efficient when the extracellular pH was slightly acidic, an opposite behaviour to that of CFTR. Considering that CF lung pathophysiology is characterized by abnormally acidic air surface liquid (Coakley et al. 2003), this could be a positive characteristic.

<p><span>Compounds <strong>69a–d</strong>. </span></p></div>
						<div class=This family belongs to the: Triazole-containing channel/carrier superfamily.

References associated with 1.D.216 family:

Coakley, R.D., B.R. Grubb, A.M. Paradiso, J.T. Gatzy, L.G. Johnson, S.M. Kreda, W.K. O''Neal, and R.C. Boucher. (2003). Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium. Proc. Natl. Acad. Sci. USA 100: 16083-16088. 14668433
Hernando, E., V. Capurro, C. Cossu, M. Fiore, M. García-Valverde, V. Soto-Cerrato, R. Pérez-Tomás, O. Moran, O. Zegarra-Moran, and R. Quesada. (2018). Small molecule anionophores promote transmembrane anion permeation matching CFTR activity. Sci Rep 8: 2608. 29422673