1.D.220. The AminoCycloDextrin Ion Channel (ACD-IC) Family
Gin and co-workers reported an aminocyclodextrin ion channel (15) that showed pH dependence due to the appended amino groups (see Fig below) (Madhavan and Gin 2007). The rate of cation transport as well as anion transport increased at a pH of 8 and above. The electrostatics of the cavity plays an important role in dictating ion transport rates. At low pH, the protonated amines strongly repel cations and attract anions. The strong anion complexation inhibits anion transport (Kumar and Madhavan 2023).