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1.D.72 The Chloride Carrier Triazine-based Tripodal Receptor (CCTTR) Family 

Triazine-based pre-organized tripodal receptors are efficient transmembrane Cl- carriers. These receptors have been designed based on a triazine core and 3,7-diazabicyclo[3.3.1]nonane arms to facilitate preorganized cavity formation. Each bicyclic arm was further functionalized to control protonation and lipophilicity which are crucial for their efficient anion binding and effective transport through liposomal membranes (Roy et al. 2016). The benzyl substituted receptor was the most effective ion transporter followed by the pentafluorobenzyl substituted derivative. The nonsubstituted receptor was least active due to its high polarity. Two active transporters were found to function as mobile carriers for Cl- via an antiport exchange mechanism. Molecular dynamic simulations with the most active receptor show a strong Cl- binding within the cavity by direct and water-mediated H-bonds with its N-H groups (Roy et al. 2016).

References associated with 1.D.72 family:

Roy, A., D. Saha, P.S. Mandal, A. Mukherjee, and P. Talukdar. (2016). pH-Gated Chloride Transport by Triazine-based Tripodal Semicage. Chemistry. [Epub: Ahead of Print] 27862455